N-油酰甘氨酸

• 常用名: N-油酰甘氨酸
• 英文名: oleoylglycine
• CAS号: 2601-90-3
• 分子量: 339.513
• 密度: 1.0±0.1 g/cm3
• 沸点: 525.6±43.0 °C at 760 mmHg
• 分子式: C₂₀H₃₇NO₃
• 熔点: N/A
• 闪点: 271.7±28.2 °C

N-油酰甘氨酸用途

N-Oleoyl glycine 是一种脂氨酸,在 3T3-L1 脂肪细胞中,能够通过激活 CB1 受体和 Akt 信号通路来刺激脂肪形成。

N-油酰甘氨酸名称

• 中文名: N-油酰甘氨酸
• 英文名: N-Oleoylglycine

N-油酰甘氨酸生物活性

• 描述: N-Oleoyl glycine 是一种脂氨酸,在 3T3-L1 脂肪细胞中,能够通过激活 CB1 受体和 Akt 信号通路来刺激脂肪形成。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  研究领域 >> 代谢疾病
  天然产物 >> 其他
• 靶点实验:

  Human Endogenous Metabolite

  CB1 Receptor

  Akt

• 体外研究: N-油酰甘氨酸是脂氨基酸,其刺激与3T3-L1脂肪细胞中CB1受体和Akt信号传导途径的活化相关的脂肪形成。通过CB1R的活化处理1-10天后,N-油酰甘氨酸(1,5,10,20,50μM)剂量和时间依赖性地刺激3T3-L1脂肪形成。在3T3-L1脂肪细胞分化过程中,N-油酰甘氨酸也会升高Akt信号通路[1]。
• 参考文献:

  [1]. Wang S, et al. N-Oleoyl glycine, a lipoamino acid, stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun. 2015 Oct 23;466(3):438-43.

N-油酰甘氨酸物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 525.6±43.0 °C at 760 mmHg
• 分子式: C₂₀H₃₇NO₃
• 分子量: 339.513
• 闪点: 271.7±28.2 °C
• 精确质量: 339.277344
• PSA: 66.40000
• LogP: 6.57
• InChIKey: HPFXACZRFJDURI-KTKRTIGZSA-N
• SMILES: CCCCCCCCC=CCCCCCCCC(=O)NCC(=O)O
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.478
• 储存条件: -20°C，密闭，干燥

N-油酰甘氨酸安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2924199090

N-油酰甘氨酸海关

• 海关编码: 2924199090
• 中文概述: 2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• Summary: 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-油酰甘氨酸靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed a... 来源：ChEMBL 靶标：Sodium- and chloride-dependent glycine transporter 2 External Id：CHEMBL4481231

实验名称：Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed a... 来源：ChEMBL 靶标：Sodium- and chloride-dependent glycine transporter 2 External Id：CHEMBL4481230

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Antiinflammatory activity against IFN-gamma-stimulated human HaCaT cells assessed as ... 来源：ChEMBL 靶标：HaCaT External Id：CHEMBL1674456

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：Cytotoxicity against human HaCaT cells at 50 to 100 uM after 24 hrs by MTT assay 来源：ChEMBL 靶标：HaCaT External Id：CHEMBL1674457

实验名称：Degradation half life in human plasma at 1000 ng/ml by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4481223

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N-油酰甘氨酸英文别名

• N-(1-Oxo-9-octadecenyl)-(Z)-glycine
• N-[(9Z)-9-Octadecenoyl]glycine
• oleoylglycine
• N-Oleoylglycine
• N-[(9Z)-Octadec-9-enoyl]glycine