GS-621763

• 常用名: GS-621763
• 英文名: GS-621763
• CAS号: 2647442-13-3
• 分子量: 501.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₁N₅O₇
• 熔点: N/A
• 闪点: N/A

GS-621763用途

GS-621763是GS-441524的一种口服生物可利用前药,在小鼠体内显示出对抗SARS-CoV-2发病机制的抗病毒活性。

GS-621763名称

• 英文名: GS-621763

GS-621763生物活性

• 描述: GS-621763是GS-441524的一种口服生物可利用前药,在小鼠体内显示出对抗SARS-CoV-2发病机制的抗病毒活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> SARS冠状病毒
• 参考文献:

  [1]. Schäfer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111.

GS-621763物理化学性质

• 分子式: C₂₄H₃₁N₅O₇
• 分子量: 501.54
• InChIKey: RVSSLHFYCSUAHY-JQGROFRJSA-N
• SMILES: CC(C)C(=O)OCC1OC(C#N)(c2ccc3c(N)ncnn23)C(OC(=O)C(C)C)C1OC(=O)C(C)C

GS-621763靶点实验

查看更多实验

实验名称：AUC(0 to 24 hrs) in SARS-CoV-2 infected mouse assessed as prodrug conversion (2R,3R,4... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324313

实验名称：Prodrug conversion in SARS-CoV-2 infected in mouse assessed as (2R,3R,4S,5R)-2-(4-ami... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324314

实验名称：Prodrug conversion in SARS-CoV-2 infected in ferret assessed as (2R,3R,4S,5R)-2-(4-am... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324311

实验名称：AUC(0 to 24 hrs) in ferret infected with SARS-CoV-2 assessed as prodrug conversion by... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324310

实验名称：Stability of compound in cynomolgus monkey liver S9 fraction assessed as half life at... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324173

实验名称：Stability of compound in human liver S9 fraction assessed as half life at pH 7.4 meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324174

实验名称：Stability of compound in rat liver S9 fraction assessed as half life at pH 7.4 measur... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324171

实验名称：Stability of compound in dog liver S9 fraction assessed as half life at pH 7.4 measur... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324172

实验名称：Stability of compound in cynomolgus monkey plasma assessed as half life measured upto... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324169

实验名称：Stability of compound in human plasma assessed as half life measured upto 4 hrs by LC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5324170

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