SOS1-IN-13

• 常用名: SOS1-IN-13
• 英文名: SOS1-IN-13
• CAS号: 2654741-45-2
• 分子量: 405.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₂F₃N₃O₂
• 熔点: N/A
• 闪点: N/A

SOS1-IN-13用途

SOS1-IN-13是无七同系物1(SOS1)抑制剂的强子,SOS1和pERK的IC50s分别为6.5 nM和327 nM。SOS1-IN-13可用于研究抗癌药物[1]。

SOS1-IN-13名称

• 英文名: SOS1-IN-13

SOS1-IN-13生物活性

• 描述: SOS1-IN-13是无七同系物1(SOS1)抑制剂的强子,SOS1和pERK的IC50s分别为6.5 nM和327 nM。SOS1-IN-13可用于研究抗癌药物[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
• 靶点实验:

  IC50: 6.5 nM (SOS1), 327 nM (pERK)[1]

• 参考文献:

  [1]. Matthew Arnold Marx, et al. Sos1 inhibitors. WO2021127429A1 (compound 4-1)

SOS1-IN-13物理化学性质

• 分子式: C₂₁H₂₂F₃N₃O₂
• 分子量: 405.41
• InChIKey: SUSQYYGPLOUGJB-GFCCVEGCSA-N
• SMILES: COc1cc2c(C)nnc(NC(C)c3cccc(C(F)(F)F)c3C)c2cc1OC

SOS1-IN-13靶点实验

查看更多实验

实验名称：Inhibiting SOS1-Mediated GTP Nucleotide Exchange by Blocking Mant-GDP Exchange from U... 来源：BindingDB 靶标：N/A External Id：BindingDB_11355_4

实验名称：HTRF Displacement Assay from US Patent US11702418: "SOS1 inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_11355_1

实验名称：Binding affinity to human recombinant SOS1 assessed as inhibition constant 来源：ChEMBL 靶标：Son of sevenless homolog 1 External Id：CHEMBL5634708

实验名称：Inhibition of ERK phosphorylation in human MKN-1 cells by Western blot analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634709

实验名称：Metabolic stability in human liver S9 fraction assessed as half life at 1 uM by LC-MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149514

实验名称：Metabolic stability in human liver S9 fraction assessed as half life at 1 uM in prese... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149515

实验名称：Antiproliferative activity against human MKN-1 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：MKN-1 External Id：CHEMBL5514031

实验名称：Binding affinity to SOS1 (unknown origin) assessed as inhibition constant by HTRF met... 来源：ChEMBL 靶标：Son of sevenless homolog 1 External Id：CHEMBL5514030

实验名称：Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in... 来源：ChEMBL 靶标：Son of sevenless homolog 1 External Id：CHEMBL5149511

实验名称：Inhibition of ERK phosphorylation in human MKN-1 cells incubated for 0.5 to 1 hr by i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149512

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