8RK64

• 常用名: 8RK64
• 英文名: 8RK64
• CAS号: 2705841-52-5
• 分子量: 360.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₆N₈O₂S
• 熔点: N/A
• 闪点: N/A

8RK64用途

8RK64是共价UCHL1抑制剂(IC50:0.32μM)[1]。

8RK64名称

• 英文名: 8RK64

8RK64生物活性

• 描述: 8RK64是共价UCHL1抑制剂(IC50:0.32μM)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 去泛素化酶
• 靶点实验:

  IC50: 0.32 μM (UCHL1), 216 µM (UCHL3)[1]

• 参考文献:

  [1]. Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841.

8RK64物理化学性质

• 分子式: C₁₄H₁₆N₈O₂S
• 分子量: 360.39

8RK64靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: N44-E168 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5060944

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Optimized Dual-Glo assay to identify co-culture induced drug vulnerabilities using do... 来源：ChEMBL 靶标：Colon cancer organoid External Id：CHEMBL5674861

实验名称：Optimized Dual-Glo assay to identify co-culture induced drug vulnerabilities using do... 来源：ChEMBL 靶标：Colon cancer organoid External Id：CHEMBL5674862

实验名称：Optimized Dual-Glo assay to identify co-culture induced drug vulnerabilities using do... 来源：ChEMBL 靶标：Colon cancer organoid External Id：CHEMBL5674863

实验名称：This assay model using primary human hepatocyte (PHH) spheroids, which are cultured i... 来源：ChEMBL 靶标：Hepatocyte spheroids External Id：CHEMBL5608110

实验名称：Targeting of F14 CAF-induced therapy resistance in O14 CRC organoid-stroma co-culture... 来源：ChEMBL 靶标：Colon cancer organoid External Id：CHEMBL5608114

实验名称：Inhibition of UCHL1 in human HEK293T cells assessed as reduction in Rho-Ub-PA-labelle... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase isozyme L1 External Id：CHEMBL5106900

实验名称：Targeting of F14 CAF-induced therapy resistance in O14 CRC organoid-stroma co-culture... 来源：ChEMBL 靶标：Colon cancer organoid External Id：CHEMBL5608115

共44条，当前第1页，共5页

1

2

3

4

5