Antiviral agent 43

• 常用名: Antiviral agent 43
• 英文名: Antiviral agent 43
• CAS号: 2739990-96-4
• 分子量: 362.82
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₂ClF₃N₂O
• 熔点: N/A
• 闪点: N/A

Antiviral agent 43用途

Antiviral agent 43 (compound 16) 是一种有效的口服活性甲型流感病毒 (influenza A viruses) 侵入抑制剂。Antiviral agent 43 抑制甲型流感病毒株 VH04-H5N1 和 PR8-H1N1 的复制,EC50 分别为 240 nM 和 72 nM。

Antiviral agent 43名称

• 英文名: Antiviral agent 43

Antiviral agent 43生物活性

• 描述: Antiviral agent 43 (compound 16) 是一种有效的口服活性甲型流感病毒 (influenza A viruses) 侵入抑制剂。Antiviral agent 43 抑制甲型流感病毒株 VH04-H5N1 和 PR8-H1N1 的复制,EC50 分别为 240 nM 和 72 nM。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 参考文献:

  [1]. Irina N Gaisina, et al. Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir. J Med Chem. 2020 Mar 26;63(6):3120-3130.

Antiviral agent 43物理化学性质

• 分子式: C₁₇H₂₂ClF₃N₂O
• 分子量: 362.82
• InChIKey: SLXIKWBDOABMIE-UHFFFAOYSA-N
• SMILES: CC(C)(C)N1CCC(NC(=O)c2ccc(C(F)(F)F)cc2Cl)CC1

Antiviral agent 43靶点实验

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实验名称：Stability in human liver microsomes assessed as compound remaining incubated for 60 m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404589

实验名称：Selectivity index, ratio of CC50 for MDCK cells to EC50 for antiviral activity agains... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404592

实验名称：Ratio of Cmax in BALB/c mouse liver at 50 mg/kg, po to EC50 for antiviral activity ag... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404593

实验名称：Half life in BALB/c mouse plasma at 10 mg/kg, ip 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404594

实验名称：Tmax in BALB/c mouse plasma at 10 mg/kg, ip 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404595

实验名称：Cmax in BALB/c mouse plasma at 10 mg/kg, ip 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404596

实验名称：Stability in mouse liver microsomes assessed as compound remaining incubated for 60 m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4404588

实验名称：Antiviral activity against pseudotyped Influenza A virus H5N1 (Goose/Qinghai/59/05) i... 来源：ChEMBL 靶标：H5N1 subtype External Id：CHEMBL4404573

实验名称：Antiviral activity against pseudotyped Influenza A virus H5N1 (Goose/Qinghai/59/05) i... 来源：ChEMBL 靶标：H5N1 subtype External Id：CHEMBL4404574

实验名称：Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL4404575

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