胡黄连苷I

更新时间：2024-01-02 16:46:55

胡黄连苷I结构式	常用名	胡黄连苷I	英文名	Picroside I
	CAS号	27409-30-9	分子量	492.473
	密度	1.6±0.1 g/cm3	沸点	739.1±60.0 °C at 760 mmHg
	分子式	C₂₄H₂₈O₁₁	熔点	130 °C
	MSDS	美版	闪点	253.2±26.4 °C

胡黄连苷I用途

Picroside I 是 Picrorhiza kurroa 的一种主要成分。Picrorhiza kurroa 是一种高价值的药用植物,富含肝脏保护代谢物 Picroside I 和 Picroside-II。Picroside I 是一种哮喘治疗药物。Picroside I 可显着减轻炎症。Picroside I 还下调 pSTAT6 和 GATA3 表达。Picroside I 剂量依赖性地增加血清 IFN-γ 水平。

中文名	胡黄连苷I
英文名	picroside i
中文别名	胡黄连苷 I
英文别名	更多

描述	Picroside I 是 Picrorhiza kurroa 的一种主要成分。Picrorhiza kurroa 是一种高价值的药用植物,富含肝脏保护代谢物 Picroside I 和 Picroside-II。Picroside I 是一种哮喘治疗药物。Picroside I 可显着减轻炎症。Picroside I 还下调 pSTAT6 和 GATA3 表达。Picroside I 剂量依赖性地增加血清 IFN-γ 水平。
相关类别	信号通路 >> 干细胞及 Wnt 通路 >> STAT 信号通路 >> JAK/STAT信号通路 >> STAT 研究领域 >> 炎症/免疫
靶点	STAT6
参考文献	[1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56. [2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782.

密度	1.6±0.1 g/cm3
沸点	739.1±60.0 °C at 760 mmHg
熔点	130 °C
分子式	C₂₄H₂₈O₁₁
分子量	492.473
闪点	253.2±26.4 °C
精确质量	492.163147
PSA	167.67000
LogP	-1.81
外观性状	固体;White to Almost white powder to crystal
蒸汽压	0.0±2.6 mmHg at 25°C
折射率	1.671
储存条件	2-8°C
水溶解性	ethanol: soluble1mg/mL, clear, colorless

危害码 (欧洲)	Xi
安全声明 (欧洲)	24/25
危险品运输编码	NONH for all modes of transport
海关编码	29389090

Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells.

Eur. J. Pharmacol. 406(2) , 203-8, (2000)

Natural iridoid, picroside I (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1, 2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate)) or II (beta-D-glucopyr...

Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells.

Life Sci. 71(15) , 1821-35, (2002)

Picrosides I and II caused a concentration-dependent (> 0.1 microM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-ind...

De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments.

BMC Genomics 13 , 126, (2012)

Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids picroside I and II, which are modulated by temperature...

picroside-1

PicrosideI

2-Propenoic acid, 3-phenyl-, (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester, (2E)-

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-

6'-O-trans-cinnamoylcatalpol

(1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-β-D-glucopyranoside

picrosides I

Picroside I

(1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl (2E)-3-phenylacrylate