Ibuzatrelvir

• 常用名: Ibuzatrelvir
• 英文名: Ibuzatrelvir
• CAS号: 2755812-39-4
• 分子量: 489.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₃₀F₃N₅O₅
• 熔点: N/A
• 闪点: N/A

Ibuzatrelvir用途

Ibuzatrelvir(PF-07817883)是一种抗病毒药物,靶向严重急性呼吸系统综合征冠状病毒2 3CL蛋白酶。Ibuzatrelvir可用于抑制新冠肺炎[1]。

Ibuzatrelvir名称

• 英文名: Ibuzatrelvir

Ibuzatrelvir生物活性

• 描述: Ibuzatrelvir(PF-07817883)是一种抗病毒药物,靶向严重急性呼吸系统综合征冠状病毒2 3CL蛋白酶。Ibuzatrelvir可用于抑制新冠肺炎[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> SARS冠状病毒
• 靶点实验:

  SARS-CoV-2 3CL protease, COVID-19[1]

• 参考文献:

  [1]. Owen, et al. Preparation of peptidomimetic nitriles as SARS-CoV-2 3CL protease inhibitors and methods for the treatment of COVID-19. World Intellectual Property Organization, WO2021250648 A1. 2021-12-16.

Ibuzatrelvir物理化学性质

• 分子式: C₂₁H₃₀F₃N₅O₅
• 分子量: 489.49
• InChIKey: WGNWEPPRWQKSKI-AIEDFZFUSA-N
• SMILES: COC(=O)NC(C(=O)N1CC(C(F)(F)F)CC1C(=O)NC(C#N)CC1CCNC1=O)C(C)(C)C

Ibuzatrelvir靶点实验

查看更多实验

实验名称：Induction of CYP3A4 enzyme activity in human hepatocytes 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5576548

实验名称：Cytotoxicity against human Hepatocyte assessed as reduction in cell viability by cell... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL5576549

实验名称：Inhibition of SARS-Cov-2 MPro assessed as inhibition constant by FRET assay 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5576423

实验名称：Antiviral activity against SARS CoV-2 USA_WA1/2020 infected in ACE2 enriched African ... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL5576424

实验名称：Passive permeability across apical to basolateral side in in dog RRCK cells incubated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5576425

实验名称：Metabolic stability in human liver microsome assessed as apparent intrinsic clearance... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5576426

实验名称：Lipophilicity, log D of compound at pH 7.4 by shake-flask method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5576427

实验名称：Clearance in Wistar Hannover rat at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5576428

实验名称：Volume of distribution at steady state in Wistar Hannover rat at 1 mg/kg, iv by LC-MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5576429

实验名称：Half life in Wistar Hannover rat at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5576430

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