LpxC-IN-9

• 常用名: LpxC-IN-9
• 英文名: LpxC-IN-9
• CAS号: 2756125-46-7
• 分子量: 451.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₅N₅O₃S
• 熔点: N/A
• 闪点: N/A

LpxC-IN-9用途

LpxC-IN-9(化合物19)是一种有效的LpxC抑制剂。LpxC-IN-9具有抗菌和降压作用[1]。

LpxC-IN-9名称

• 英文名: LpxC-IN-9

LpxC-IN-9生物活性

• 描述: LpxC-IN-9(化合物19)是一种有效的LpxC抑制剂。LpxC-IN-9具有抗菌和降压作用[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Takeru Furuya, et al. N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. Bioorg Med Chem. 2020 Dec 15;28(24):115826.

LpxC-IN-9物理化学性质

• 分子式: C₂₃H₂₅N₅O₃S
• 分子量: 451.54

LpxC-IN-9靶点实验

查看更多实验

实验名称：Inhibition of human AchE expressed in HEK293 cells using acetylthiocholine as substra... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4705095

实验名称：Antibacterial activity against Escherichia coli ARC6599 infected in cyclophosphamide-... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4705094

实验名称：Antibacterial activity against Escherichia coli ARC6599 infected in sc dosed cyclopho... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4705097

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 90 mg/kg, iv administ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705099

实验名称：Clearance in Sprague-Dawley rat at 90 mg/kg, iv administered as single bolus dose by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705098

实验名称：AUC in mouse at 200 mg/kg, sc 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705087

实验名称：Volume of distribution in mouse at 200 mg/kg, sc 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705089

实验名称：Observed clearance in mouse at 200 mg/kg, sc 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705088

实验名称：Protein binding in mouse plasma assessed as unbound fraction after 7 hrs by LC-MS/MS-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705091

实验名称：Ratio of fAUC in mouse at 200 mg/kg, sc to MIC for antibacterial activity against Esc... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705090

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