TNG908

更新时间：2025-08-25 12:37:41

TNG908结构式	常用名	TNG908	英文名	TNG908
	CAS号	2760481-53-4	分子量	409.50
	密度	N/A	沸点	N/A
	分子式	C₂₁H₂₃N₅O₂S	熔点	N/A
	MSDS	N/A	闪点	N/A

TNG908用途

TNG908是一种MTAP协同PRMT5抑制剂,可穿过血脑屏障。TNG908对MTAP阴性细胞系的选择性是MTAPWT细胞系的15倍,可以用于癌症研究[1]。

英文名	TNG908

描述	TNG908是一种MTAP协同PRMT5抑制剂,可穿过血脑屏障。TNG908对MTAP阴性细胞系的选择性是MTAPWT细胞系的15倍,可以用于癌症研究[1]。
相关类别	研究领域 >> 癌症信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
参考文献	[1]. K. Briggs, et al. TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted cancer.MOLECULAR TARGETED AGENTS 2\| VOLUME 174, SUPPLEMENT 1, S84, OCTOBER 2022.

分子式	C₂₁H₂₃N₅O₂S
分子量	409.50
InChIKey	NXXBDYHMHHINFC-YVEFUNNKSA-N
SMILES	Cc1cc(NC(=O)C(=O)N2CC(C)CCC2c2ccc3scnc3c2)cnc1N

实验名称：Inhibition of DOT1L (unknown origin) at 1 to 10 uM using Nucleosomes as substrate
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase, H3 lysine-79 specific
External Id：CHEMBL5547707

实验名称：Inhibition of DNMT3b/3L (unknown origin) at 1 to 10 uM using Lambda DNA as substrate
来源：ChEMBL
靶标：DNA (cytosine-5)-methyltransferase 3-like
External Id：CHEMBL5547708

实验名称：Inhibition of EZH1 (unknown origin) at 1 to 10 uM using Core Histone as substrate
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase EZH1
External Id：CHEMBL5547709

实验名称：Inhibition of EZH2 (unknown origin) at 1 to 10 uM using Core Histone as substrate
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase EZH2
External Id：CHEMBL5547710

实验名称：Inhibition of EZH2 Y641F mutant (unknown origin) at 1 to 10 uM using Core Histone as ...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase EZH2
External Id：CHEMBL5547711

实验名称：Inhibition of G9a (unknown origin) at 1 to 10 uM using Histone H3 (1 to 21) peptide a...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase EHMT2
External Id：CHEMBL5547712

实验名称：Inhibition of GLP (unknown origin) at 1 to 10 uM using Histone H3 (1 to 21) peptide a...
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase EHMT1
External Id：CHEMBL5547713

实验名称：Inhibition of MLL1 (unknown origin) at 1 to 10 uM using Nucleosomes as substrate
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase 2A
External Id：CHEMBL5547714

实验名称：Inhibition of MLL2 (unknown origin) at 1 to 10 uM using Nucleosomes as substrate
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase 2D
External Id：CHEMBL5547715

实验名称：Inhibition of MLL3 (unknown origin) at 1 to 10 uM using Nucleosomes as substrate
来源：ChEMBL
靶标：Histone-lysine N-methyltransferase 2C
External Id：CHEMBL5547716

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