Antiviral agent 35

• 常用名: Antiviral agent 35
• 英文名: Antiviral agent 35
• CAS号: 2760972-52-7
• 分子量: 418.47
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₁₈N₂O₄S
• 熔点: N/A
• 闪点: N/A

Antiviral agent 35用途

Antiviral agent 35 (compound 4d) 是一种口服有效的流感病毒 (influenza virus) 抑制剂,在病毒复制的早期阶段发挥作用。 Antiviral agent 35 可抑制流感病毒诱导的 ROS 积累、自噬和细胞凋亡 (apoptosis),并抑制肺部感染小鼠模型中RIG-1通路介导的炎症反应。Antiviral agent 35 的细胞毒性低 (CC50 >800 μM,MDCK 细胞),还具有抗 H1N1 (A/Weiss/43) 活性,EC50=2.28 μM。

Antiviral agent 35名称

• 英文名: Antiviral agent 35

Antiviral agent 35生物活性

• 描述: Antiviral agent 35 (compound 4d) 是一种口服有效的流感病毒 (influenza virus) 抑制剂,在病毒复制的早期阶段发挥作用。 Antiviral agent 35 可抑制流感病毒诱导的 ROS 积累、自噬和细胞凋亡 (apoptosis),并抑制肺部感染小鼠模型中RIG-1通路介导的炎症反应。Antiviral agent 35 的细胞毒性低 (CC50 >800 μM,MDCK 细胞),还具有抗 H1N1 (A/Weiss/43) 活性,EC50=2.28 μM。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 靶点实验:

  EC50: 2.28 μM (HINI A/Weiss/43), 3.34 μM (A/Virginia/ATCC2/2009), 6.61 μM (A/Califomia/2014)[1]

• 参考文献:

  [1]. Ge Y, et al. Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo. Eur J Med Chem. 2023 Nov 5;259:115660.

Antiviral agent 35物理化学性质

• 分子式: C₂₃H₁₈N₂O₄S
• 分子量: 418.47
• InChIKey: GJZCHLIWCQDKMK-UHFFFAOYSA-N
• SMILES: O=[N+]([O-])c1ccc(S(=O)(=O)N(Cc2ccccc2)c2cccc3ccccc23)cc1

Antiviral agent 35靶点实验

查看更多实验

实验名称：Antiviral activity against Influenza A virus H1N1 infected in human A549 cells assess... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627277

实验名称：Antiviral activity against Influenza A virus H1N1 infected in human A549 cells assess... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627278

实验名称：Antiviral activity against Influenza A virus H1N1 infected in human A549 cells assess... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627279

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Weiss/43)-infected in BALB/c mou... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627280

实验名称：Toxicity in BALB/c mouse infected with Influenza A virus H1N1 (A/Weiss/43) assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627281

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Weiss/43)-infected in BALB/c mou... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627282

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Weiss/43)-infected in BALB/c mou... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627283

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Weiss/43)-infected in BALB/c mou... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627284

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Weiss/43)-infected in BALB/c mou... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627285

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Weiss/43)-infected in BALB/c mou... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627286

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