Anti-osteoporosis agent-1

• 常用名: Anti-osteoporosis agent-1
• 英文名: Anti-osteoporosis agent-1
• CAS号: 2761577-50-6
• 分子量: 354.83
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉ClN₂O₂
• 熔点: N/A
• 闪点: N/A

Anti-osteoporosis agent-1用途

抗骨质疏松剂-1(comp 4aa)是一种有效的复制蛋白a(RPA)抑制剂(IC50=18µM)[1]。

Anti-osteoporosis agent-1名称

• 英文名: Anti-osteoporosis agent-1

Anti-osteoporosis agent-1生物活性

• 描述: 抗骨质疏松剂-1(comp 4aa)是一种有效的复制蛋白a(RPA)抑制剂(IC50=18µM)[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 炎症/免疫
• 体外研究: 抗骨质疏松剂-1是一种活性分子,可有效矿化成骨细胞,并在转录和翻译水平上调Bmp-2、Runx-2和Type-1col等成骨标记基因。除了表现出潜在的成骨活性。此外,抗骨质疏松剂-1在1μm和100μm浓度下也具有显著的抗凋亡活性,并在缺乏血清的情况下提高成骨细胞的存活率[1]。
• 参考文献:

  [1]. Kriti Sharma, et al. Pyrazoline analogues: Design, synthesis, and evaluation of anti-osteoporosis activity. Bioorg Med Chem Lett. 2022 Mar 15; 60:128585.

Anti-osteoporosis agent-1物理化学性质

• 分子式: C₂₀H₁₉ClN₂O₂
• 分子量: 354.83

Anti-osteoporosis agent-1靶点实验

查看更多实验

实验名称：Cytoprotective activity against serum deprivation-induced apoptosis in mouse calvaria... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5134084

实验名称：Cytoprotective activity against serum deprivation-induced apoptosis in mouse calvaria... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5134085

实验名称：Induction of osteoblast differentiation in mouse calvarial osteoblasts assessed as in... 来源：ChEMBL 靶标：Calvarial osteoblast External Id：CHEMBL5134080

实验名称：Induction of osteoblast differentiation in mouse calvarial osteoblasts assessed as in... 来源：ChEMBL 靶标：Calvarial osteoblast External Id：CHEMBL5134081

实验名称：Induction of osteoblast differentiation in mouse calvarial osteoblasts assessed as in... 来源：ChEMBL 靶标：Calvarial osteoblast External Id：CHEMBL5134082

实验名称：Induction of osteoblast differentiation in mouse calvarial osteoblasts assessed as in... 来源：ChEMBL 靶标：Calvarial osteoblast External Id：CHEMBL5134083

实验名称：Induction of new bone formation in BMSC cells (unknown origin) assessed as increase i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5134076

实验名称：Induction of new bone formation in mouse calvarial osteoblasts assessed as increase i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5134077

实验名称：Induction of osteoblast differentiation in mouse calvarial osteoblasts assessed as in... 来源：ChEMBL 靶标：Calvarial osteoblast External Id：CHEMBL5134078

实验名称：Induction of osteoblast differentiation in mouse calvarial osteoblasts assessed as in... 来源：ChEMBL 靶标：Calvarial osteoblast External Id：CHEMBL5134079

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