HL-8

• 常用名: HL-8
• 英文名: HL-8
• CAS号: 2766352-64-9
• 分子量: 1144.27
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₇H₅₉F₂N₁₁O₉S₂
• 熔点: N/A
• 闪点: N/A

HL-8用途

HL-8是一种靶向PI3K激酶的PROTAC分子。HL-8在8小时内浓度为10μM时,对PI3K激酶有显著而完全的降解作用。HL-8在癌症疾病研究中具有潜在的应用前景[1]。

HL-8名称

• 英文名: HL-8

HL-8生物活性

• 描述: HL-8是一种靶向PI3K激酶的PROTAC分子。HL-8在8小时内浓度为10μM时,对PI3K激酶有显著而完全的降解作用。HL-8在癌症疾病研究中具有潜在的应用前景[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 参考文献:

  [1]. Wang H, et al. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase. Bioorg Med Chem. 2022 May 1;61:116707.

HL-8物理化学性质

• 分子式: C₅₇H₅₉F₂N₁₁O₉S₂
• 分子量: 1144.27
• InChIKey: ACMMTSCGBPIHNT-RMNSFAHDSA-N
• SMILES: COc1ncc(-c2ccc3ncc(-c4nnc(-c5ccccc5C(=O)NCCCCCCC(=O)NC(C(=O)N5CC(O)CC5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)o4)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F

HL-8靶点实验

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实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as inhibition of AKT phospho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122347

实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as reduction in AKT phosphor... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122343

实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as induction of PI3Kalpha de... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122344

实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as redcution in AKT phosphor... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122345

实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as induction of PI3Kalpha de... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122346

实验名称：Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5122339

实验名称：Antiproliferative activity against human HeLa cells assessed as inhibition of cell pr... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5122340

实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as induction of PI3Kalpha de... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122341

实验名称：PROTAC activity at VHL/PI3K in human HeLa cells assessed as induction of PI3Kalpha de... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5122342

实验名称：Inhibition on PI3Kalpha (unknown origin) at 1 nM by kinase-glo plus luminescent assay... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL5122337

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