TLR7 agonist 16

• 常用名: TLR7 agonist 16
• 英文名: TLR7 agonist 16
• CAS号: 2832199-56-9
• 分子量: 431.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₉N₅O₂
• 熔点: N/A
• 闪点: N/A

TLR7 agonist 16用途

TLR7 agonist 16 (compound 16d) 是一种高效 TLR7 激动剂,EC50 为 59 nM。TLR7 agonist 16 在低纳摩尔浓度下可有效诱导小鼠巨噬细胞和 hPBMC 的激活。

TLR7 agonist 16名称

• 英文名: TLR7 agonist 16

TLR7 agonist 16生物活性

• 描述: TLR7 agonist 16 (compound 16d) 是一种高效 TLR7 激动剂,EC50 为 59 nM。TLR7 agonist 16 在低纳摩尔浓度下可有效诱导小鼠巨噬细胞和 hPBMC 的激活。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14(10):1358-1368.

TLR7 agonist 16物理化学性质

• 分子式: C₂₅H₂₉N₅O₂
• 分子量: 431.53

TLR7 agonist 16靶点实验

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实验名称：Agonist activity at TLR7 in human PBMC cells assessed as increase in IFNalpha release... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370445

实验名称：Agonist activity at TLR7 in human PBMC cells assessed as increase in TNFalpha release... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370443

实验名称：Apparent permeability of the compound at 200 uM incubated for 5 hrs by PAMPA assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL5370444

实验名称：Agonist activity at TLR7 in human Ramos-blue cells assessed as increase in NFkappaB a... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370441

实验名称：Agonist activity at TLR7 in mouse RAW264.7 cells assessed as increase in NFkappaB act... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370442

实验名称：Agonist activity at TLR7 in human Ramos blue cells assessed as lowest concentration t... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370440

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