STA-21(Ochromycinone)

• 常用名: STA-21(Ochromycinone)
• 英文名: STA-21(Ochromycinone)
• CAS号: 28882-53-3
• 分子量: 306.31
• 密度: 1.4±0.1 g/cm3
• 沸点: 568.6±50.0 °C at 760 mmHg
• 分子式: C₁₉H₁₄O₄
• 熔点: 160-162ºC
• 闪点: 311.7±26.6 °C

STA-21(Ochromycinone)用途

(+)-赭霉素是一种天然抗生素,可有效抑制STAT3。(+)-赭霉素用于癌症和银屑病的研究[1][2]。

STA-21(Ochromycinone)名称

• 英文名: Ochromycinone

STA-21(Ochromycinone)生物活性

• 描述: (+)-赭霉素是一种天然抗生素,可有效抑制STAT3。(+)-赭霉素用于癌症和银屑病的研究[1][2]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> STAT
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> STAT
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5.

  [2]. Miyoshi K, et al. Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. J Invest Dermatol. 2011 Jan;131(1):108-17.

STA-21(Ochromycinone)物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 568.6±50.0 °C at 760 mmHg
• 熔点: 160-162ºC
• 分子式: C₁₉H₁₄O₄
• 分子量: 306.31
• 闪点: 311.7±26.6 °C
• 精确质量: 306.089203
• PSA: 71.44000
• LogP: 4.86
• InChIKey: ZAWXOCUFQSQDJS-VIFPVBQESA-N
• SMILES: CC1CC(=O)c2c(ccc3c2C(=O)c2cccc(O)c2C3=O)C1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.667

STA-21(Ochromycinone)安全信息

• 海关编码: 2914400090

STA-21(Ochromycinone)海关

• 海关编码: 2914400090
• 中文概述: 2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

STA-21(Ochromycinone)靶点实验

查看更多实验

实验名称：Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL929985

实验名称：Inhibition of STAT3 binding to DNA 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL929981

实验名称：Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL929982

实验名称：Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL929983

实验名称：Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：LNCaP External Id：CHEMBL929984

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Inhibition of STAT3 in human MDA-MB-435 cells at 20 uM after 48 hrs by luciferase rep... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL2175199

实验名称：Hit confirmation of the active molecules of the enzymatic assay of human HDAC6 with c... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808151

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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STA-21(Ochromycinone)英文别名

• (3S)-8-Hydroxy-3-methyl-3,4-dihydro-1,7,12(2H)-tetraphenetrione
• (3S)-8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione
• (3S)-8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione