JAK-IN-30

• 常用名: JAK-IN-30
• 英文名: JAK-IN-30
• CAS号: 2891469-99-9
• 分子量: 398.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₆N₈S
• 熔点: N/A
• 闪点: N/A

JAK-IN-30用途

JAK-IN-30(化合物31)是一种水溶性JAK抑制剂,其对JAK2、JAK1、JAK3和TYK2的IC50值分别为2、15、18和2nM。JAK-IN-30具有治疗干眼病(DED)的研究潜力[1]。

JAK-IN-30名称

• 英文名: JAK-IN-30

JAK-IN-30生物活性

• 描述: JAK-IN-30(化合物31)是一种水溶性JAK抑制剂,其对JAK2、JAK1、JAK3和TYK2的IC50值分别为2、15、18和2nM。JAK-IN-30具有治疗干眼病(DED)的研究潜力[1]。
• 相关类别:
  信号通路 >> JAK/STAT信号通路 >> JAK
  信号通路 >> 表观遗传学 >> JAK
  信号通路 >> 干细胞及 Wnt 通路 >> JAK
  研究领域 >> 炎症/免疫
• 靶点实验:

  JAK1:15 nM (IC50)

  JAK2:2 nM (IC50)

  JAK3:18 nM (IC50)

  Tyk2:2 nM (IC50)

• 参考文献:

  [1]. Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950.

JAK-IN-30物理化学性质

• 分子式: C₁₉H₂₆N₈S
• 分子量: 398.53
• InChIKey: VGBYAYCYPVFDTM-UHFFFAOYSA-N
• SMILES: Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCN(C)CC4)C3)n2)sn1

JAK-IN-30靶点实验

查看更多实验

实验名称：Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated ... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL5334095

实验名称：Cytotoxicity against human TK6 cells assessed as concentration required for 3 fold in... 来源：ChEMBL 靶标：TK6 External Id：CHEMBL5334096

实验名称：Inhibition of JAK3 (unknown origin) incubated for 45 to 120 mins in presence of ATP b... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL5334093

实验名称：Inhibition of TYK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP b... 来源：ChEMBL 靶标：Non-receptor tyrosine-protein kinase TYK2 External Id：CHEMBL5334094

实验名称：Inhibition of JAK1 (unknown origin) incubated for 45 to 120 mins in presence of ATP b... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL5334091

实验名称：Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP b... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL5334092

实验名称：Antiinflammatory activity in C57BL/6J allergic eye diseased mouse model assessed as r... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5334107

实验名称：In vivo inhibition of JAK-STAT pathway in C57BL/6J allergic eye diseased mouse model ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5334105

实验名称：Antiinflammatory activity in C57BL/6J allergic eye diseased mouse model assessed as r... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5334103

实验名称：Inhibition of GSK3B (unknown origin) incubated for 45 to 120 mins in presence of ATP ... 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5334101

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