JAK-IN-30

Modify Date: 2025-09-29 10:14:15

JAK-IN-30 structure	Common Name	JAK-IN-30
	CAS Number	2891469-99-9	Molecular Weight	398.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₆N₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK-IN-30

JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].

Name	JAK-IN-30

Description	JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:15 nM (IC50) JAK2:2 nM (IC50) JAK3:18 nM (IC50) Tyk2:2 nM (IC50)
References	[1]. Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950.

Molecular Formula	C₁₉H₂₆N₈S
Molecular Weight	398.53
InChIKey	VGBYAYCYPVFDTM-UHFFFAOYSA-N
SMILES	Cc1cc(Nc2ncc(C)c(N3CC(CC#N)(N4CCN(C)CC4)C3)n2)sn1

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