BDM91270

• 常用名: BDM91270
• 英文名: BDM91270
• CAS号: 2892824-11-0
• 分子量: 419.73
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₁Cl₃N₄O₂
• 熔点: N/A
• 闪点: N/A

BDM91270用途

BDM91270(化合物29)是一种大肠杆菌AcrAB-TolC外排泵抑制剂,对野生型大肠杆菌AcrB的EC90为0.6μM。BDM91270可用于大肠杆菌耐药性的研究[1]。

BDM91270名称

• 英文名: BDM91270

BDM91270生物活性

• 描述: BDM91270(化合物29)是一种大肠杆菌AcrAB-TolC外排泵抑制剂,对野生型大肠杆菌AcrB的EC90为0.6μM。BDM91270可用于大肠杆菌耐药性的研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  EC90: 0.6 μM (AcrB)[1].

• 参考文献:

  [1]. Compagne N, et al. Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump. Eur J Med Chem. 2023 Jul 7;259:115630.

BDM91270物理化学性质

• 分子式: C₁₇H₂₁Cl₃N₄O₂
• 分子量: 419.73
• InChIKey: GKQBSWGNHZXAHN-UHFFFAOYSA-N
• SMILES: Cl.Cl.NCc1cccc(OC(=O)c2cnc(N3CCNCC3)c(Cl)c2)c1

BDM91270靶点实验

查看更多实验

实验名称：Potentiation of novobiocin induced antibacterial activity in Escherichia coli BW25113... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5634462

实验名称：Potentiation of linezolid induced antibacterial activity in Escherichia coli BW25113 ... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5634463

实验名称：Potentiation of erythromycin induced antibacterial activity in Escherichia coli BW251... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5634464

实验名称：Potentiation of ciprofloxacin induced antibacterial activity in Escherichia coli BW25... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5634465

实验名称：Stability in mouse plasma assessed as half life at 10 uM measured up to 360 mins by L... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634467

实验名称：Stability in CD-1 mouse liver microsomes assessed as half life at 1 uM measured up to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634468

实验名称：Stability in CD-1 mouse liver microsomes assessed as intrinsic clearance at 1 uM meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634469

实验名称：Potency index, ratio of BDM88832 EC90 to test compound EC90 for inhibition of AcrAB-T... 来源：ChEMBL 靶标：Multidrug efflux pump subunit AcrB External Id：CHEMBL5634470

实验名称：Antibacterial activity against Escherichia coli BW25113 assessed as reduction in bact... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5634437

实验名称：Inhibition of AcrB in Escherichia coli BW25113 assessed as potentiation of pyridomyci... 来源：ChEMBL 靶标：Multidrug efflux pump subunit AcrB External Id：CHEMBL5634440

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