SIRT5 inhibitor 7

• 常用名: SIRT5 inhibitor 7
• 英文名: SIRT5 inhibitor 7
• CAS号: 2951090-00-7
• 分子量: 582.12
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₂ClN₇O₃S
• 熔点: N/A
• 闪点: N/A

SIRT5 inhibitor 7用途

SIRT5 inhibitor 7 (compound 58) 是底物竞争性和选择性的 SIRT5 抑制剂,具有抗炎活性。SIRT5 inhibitor 7 具有肾功能保护作用,调节蛋白质琥珀酰化和促炎细胞因子的释放。SIRT5 inhibitor 7 在脂多糖 (LPS) 和盲肠结扎/穿孔 (CLP) 诱导的脓脓毒症相关的急性肾损伤 AKI 小鼠模型中具有体内活性。

SIRT5 inhibitor 7名称

• 英文名: SIRT5 inhibitor 7

SIRT5 inhibitor 7生物活性

• 描述: SIRT5 inhibitor 7 (compound 58) 是底物竞争性和选择性的 SIRT5 抑制剂,具有抗炎活性。SIRT5 inhibitor 7 具有肾功能保护作用,调节蛋白质琥珀酰化和促炎细胞因子的释放。SIRT5 inhibitor 7 在脂多糖 (LPS) 和盲肠结扎/穿孔 (CLP) 诱导的脓脓毒症相关的急性肾损伤 AKI 小鼠模型中具有体内活性。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 310 nM (SIRT5)[1]

• 参考文献:

  [1]. Mou L, et al. Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535..

SIRT5 inhibitor 7物理化学性质

• 分子式: C₂₈H₃₂ClN₇O₃S
• 分子量: 582.12
• InChIKey: YVUGRSDTNXBWNT-FQEVSTJZSA-N
• SMILES: O=C(O)CCNC(=S)NCCCNc1nc(Nc2ccccc2Cl)ncc1C(=O)N1CCC(c2ccccc2)C1

SIRT5 inhibitor 7靶点实验

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实验名称：Binding affinity to human SIRT5 (34 to 269 residues) assessed as thermal stabilizatio... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364479

实验名称：Binding affinity to human SIRT5 (34 to 269 residues) assessed as thermal stabilizatio... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364476

实验名称：Binding affinity to human SIRT5 (34 to 269 residues) assessed as thermal stabilizatio... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364477

实验名称：Competitive inhibition of human SIRT5 (34 to 269 residues) using varying concentratio... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364474

实验名称：Competitive inhibition of human SIRT5 (34 to 269 residues) using varying concentratio... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364472

实验名称：Competitive inhibition of human SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364473

实验名称：Inhibition of human SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as f... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364471

实验名称：Hepatoprotective activity in C57BL/6J mouse model of CLP-induced septic acute kidney ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5364510

实验名称：Hepatoprotective activity in C57BL/6J mouse model of CLP-induced septic acute kidney ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5364511

实验名称：Hepatoprotective activity in C57BL/6J mouse model of LPS-induced septic acute kidney ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5364508

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