SIRT5 inhibitor 7

Modify Date: 2025-08-27 18:15:46

SIRT5 inhibitor 7 Structure
SIRT5 inhibitor 7 structure
 Common Name SIRT5 inhibitor 7
CAS Number 2951090-00-7 Molecular Weight 582.12
Density N/A Boiling Point N/A
Molecular Formula C28H32ClN7O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SIRT5 inhibitor 7


SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].

 Names

Name SIRT5 inhibitor 7

 SIRT5 inhibitor 7 Biological Activity

Description SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].
Related Catalog
Target

IC50: 310 nM (SIRT5)[1]

References

[1]. Mou L, et al. Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535..  

 Chemical & Physical Properties

Molecular Formula C28H32ClN7O3S
Molecular Weight 582.12
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