Ciluprevir

• 常用名: Ciluprevir
• 英文名: Ciluprevir
• CAS号: 300832-84-2
• 分子量: 774.93
• 密度: 1.4±0.0 g/cm3
• 沸点: N/A
• 分子式: C₄₀H₅₀N₆O₈S
• 熔点: N/A
• 闪点: N/A

Ciluprevir用途

Ciluprevir(BILN 2061)是HCV NS3蛋白酶的特异性和有效的拟肽抑制剂,IC50为3.0nM。

Ciluprevir名称

• 中文名: 西鲁瑞韦
• 英文名: 75C8DU40T0

Ciluprevir生物活性

• 描述: Ciluprevir(BILN 2061)是HCV NS3蛋白酶的特异性和有效的拟肽抑制剂,IC50为3.0nM。
• 相关类别:
  信号通路 >> 抗感染 >> HCV
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> HCV蛋白酶
• 参考文献:

  [1]. Llinàs-Brunet M, et al. Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061. J Med Chem. 2004 Mar 25;47(7):1605-8.

  [2]. Thibeault D, et al. Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061. J Virol. 2004 Jul;78(14):7352-9.

  [3]. Lamarre D, et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature. 2003 Nov 13;426(6963):186-9.

  [4]. Reiser M, et al. Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology. 2005 Apr;41(4):832-5.

Ciluprevir物理化学性质

• 密度: 1.4±0.0 g/cm3
• 分子式: C₄₀H₅₀N₆O₈S
• 分子量: 774.93
• 精确质量: 774.341064
• LogP: 5.85
• InChIKey: PJZPDFUUXKKDNB-OADLQNFBSA-N
• SMILES: COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCC(NC(=O)OC5CCCC5)C(=O)N4C3)cc(-c3csc(NC(C)C)n3)nc2c1
• 折射率: 1.652
• 储存条件: 2-8℃

Ciluprevir靶点实验

查看更多实验

实验名称：Inhibition of HCV 1a NS3/4A protease 来源：ChEMBL 靶标：N/A External Id：CHEMBL1780535

实验名称：Antiviral activity against HCV genotype 1b infected in Huh7 cells assessed as inhibit... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1780534

实验名称：Bioavailability in rat (dose 5 mg/kg i.v.) 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL783020

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 D168V mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266348

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 R155K mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266356

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 R155Q mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266355

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 A156T mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266354

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 D168V mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266353

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 V170A mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266352

实验名称：Selectivity ratio of EC50 for Hepatitis C virus genotype 1b N expressing NS3 R155K mu... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1266351

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Ciluprevir英文别名

• (2R,6S,12E,13aS,14aR,16aS)-6-{[(cyclopentyloxy)carbonyl]amino}-2-({7-methoxy-2-[2-(propan-2-ylamino)-1,3-thiazol-4-yl]quinolin-4-yl}oxy)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid
• 75C8DU40T0
• (2R,6S,12E,13aS,14aR,16aS)-6-{[(Cyclopentyloxy)carbonyl]amino}-2-({2-[2-(isopropylamino)-1,3-thiazol-4-yl]-7-methoxy-4-quinolinyl}oxy)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid