ZIM

• 常用名: ZIM
• 英文名: ZIM
• CAS号: 301298-87-3
• 分子量: 349.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉N₃O₃
• 熔点: N/A
• 闪点: N/A

ZIM用途

ZIM是一种源自4-氨基安替比林的降冰片烯,是DNA损伤的有效诱导剂,可导致基因组和染色体损伤,并诱导细胞死亡和激活吞噬功能。ZIM在癌症研究中具有化疗潜力[1]。

ZIM名称

• 英文名: ZIM

ZIM生物活性

• 描述: ZIM是一种源自4-氨基安替比林的降冰片烯,是DNA损伤的有效诱导剂,可导致基因组和染色体损伤,并诱导细胞死亡和激活吞噬功能。ZIM在癌症研究中具有化疗潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 体内研究: ZIM(i.p.,12、24和48 mg/kg)在成年雄性瑞士小鼠中,可以有效降低所有剂量在 24和 72小时的染色体微核频率,具有一定的化学预防作用,并且损伤降低的百分比范围为 38.36至 83.26%[1]。 ZIM(i.p.,12、24和48 mg/kg)可以降低由 顺铂CIS和 多柔比星DOX诱导的肝脏细胞和肾脏细胞死亡频率。在 12、24和 48毫克/千克的剂量浓度下,其中 顺式组中肝脏的损伤降低百分比分别为 79.27、75.20 和 52.84%,脱氧核糖核酸组的损伤降低百分比分别为 62.06、59.44 和 77.80%。顺式组的肾脏损伤减少百分比为 45.29、36.09 和 41.61%,脱氧核糖核酸为 28.00、21.41 和 30.82%[1]。
• 参考文献:

  [1]. Rodrigo Juliano Oliveira, et al. ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics. Chem Res Toxicol. 2022 Dec 22.

ZIM物理化学性质

• 分子式: C₂₀H₁₉N₃O₃
• 分子量: 349.38
• InChIKey: QOOKFECIGXERRL-UHFFFAOYSA-N
• SMILES: Cc1c(N2C(=O)C3C4C=CC(C4)C3C2=O)c(=O)n(-c2ccccc2)n1C

ZIM靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：qHTS of TDP-43 Inhibitors: NCGC Sytravon Library Screen 来源：NCGC External Id：tdp43-p2-repeat

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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