LU AA33810

• 常用名: LU AA33810
• 英文名: LU AA33810
• CAS号: 304008-29-5
• 分子量: 423.61600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₅N₃O₂S₃
• 熔点: N/A
• 闪点: N/A

LU AA33810用途

Lu AA33810是神经肽Y5受体的有效和选择性拮抗剂,对人类受体的Ki为1.5 nM。Lu AA33810显示出抗焦虑药样和抗抑郁药样作用[1]。

LU AA33810名称

• 英文名: N-{[trans-4-(4,5-Dihydro[1]benzothiepino[5,4-d][1,3]thiazol-2-yla mino)cyclohexyl]methyl}methanesulfonamide

LU AA33810生物活性

• 描述: Lu AA33810是神经肽Y5受体的有效和选择性拮抗剂,对人类受体的Ki为1.5 nM。Lu AA33810显示出抗焦虑药样和抗抑郁药样作用[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
• 靶点实验:

  hY5 receptor:1.5 nM (Ki)

• 参考文献:

  [1]. Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11.

LU AA33810物理化学性质

• 分子式: C₁₉H₂₅N₃O₂S₃
• 分子量: 423.61600
• 精确质量: 423.11100
• PSA: 136.24000
• LogP: 4.87180
• InChIKey: UWSBTSAJZMIHBL-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)NCC1CCC(CC1)NC2=NC3=C(S2)CCSC4=CC=CC=C43

LU AA33810靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

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实验名称：PDSP Secondary Binding target: TMEM97 - Compounds are tested at 10 uM concentration, ... 来源：ChEMBL 靶标：Sigma intracellular receptor 2 External Id：CHEMBL5442185

实验名称：PDSP Secondary Binding target: HTR5A - Compounds are tested at 10 uM concentration, p... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 5A External Id：CHEMBL5442181

实验名称：PDSP Secondary Binding target: HTR1D - Compounds are tested at 10 uM concentration, p... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1D External Id：CHEMBL5442180

实验名称：PDSP Primary Binding target: CHRM1 - Compounds are tested at 10 uM concentration, pla... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL5442228

实验名称：PDSP Primary Binding target: ADRB2 - Compounds are tested at 10 uM concentration, pla... 来源：ChEMBL 靶标：Beta-2 adrenergic receptor External Id：CHEMBL5442227

实验名称：PDSP Primary Binding target: ADRB1 - Compounds are tested at 10 uM concentration, pla... 来源：ChEMBL 靶标：Beta-1 adrenergic receptor External Id：CHEMBL5442226

实验名称：PDSP Primary Binding target: ADRA2C - Compounds are tested at 10 uM concentration, pl... 来源：ChEMBL 靶标：Alpha-2C adrenergic receptor External Id：CHEMBL5442225

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