BRD4-IN-4

• 常用名: BRD4-IN-4
• 英文名: BRD4-IN-4
• CAS号: 304685-40-3
• 分子量: 330.40
• 密度: 1.4±0.1 g/cm3
• 沸点: 559.0±56.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈N₂O₃S
• 熔点: N/A
• 闪点: 291.8±31.8 °C

BRD4-IN-4用途

BRD4-IN-4(化合物1)是一种BRD4抑制剂(IC50＝6.83μM)。BRD4-IN-4选择性地抑制MV4-11细胞系的增殖并使细胞停滞在G1期。BRD4-IN-4可用于MLL白血病的研究[1]。

BRD4-IN-4名称

• 英文名: WAY-383515

BRD4-IN-4生物活性

• 描述: BRD4-IN-4(化合物1)是一种BRD4抑制剂(IC50＝6.83μM)。BRD4-IN-4选择性地抑制MV4-11细胞系的增殖并使细胞停滞在G1期。BRD4-IN-4可用于MLL白血病的研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  IC50: 6.83 μM (BRD4)[1]

• 参考文献:

  [1]. Feng Y, et al. Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors. Eur J Med Chem. 2018 May 25;152:264-273.

BRD4-IN-4物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 559.0±56.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈N₂O₃S
• 分子量: 330.40
• 闪点: 291.8±31.8 °C
• 精确质量: 330.103821
• LogP: 1.80
• InChIKey: HTONIJRZZRKKQF-UHFFFAOYSA-N
• SMILES: CCN1C(=O)c2cccc3c(S(=O)(=O)N4CCCC4)ccc1c23
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.675
• 储存条件: -80℃储存

BRD4-IN-4靶点实验

查看更多实验

实验名称：Antiproliferative activity against human 22Rv1 cells after 72 hrs by CellTiter-Glo lu... 来源：ChEMBL 靶标：CWR22R External Id：CHEMBL4154443

实验名称：Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase after 24... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4154444

实验名称：Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase at 5 uM ... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4154445

实验名称：Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2-phase at 5 uM ... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4154446

实验名称：Antiproliferative activity against human MRC5 cells after 72 hrs by CellTiter-Glo lum... 来源：ChEMBL 靶标：MRC5 External Id：CHEMBL4154439

实验名称：Antiproliferative activity against human RPTEC cells after 72 hrs by CellTiter-Glo lu... 来源：ChEMBL 靶标：RPTEC External Id：CHEMBL4154440

实验名称：Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter-G... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4154441

实验名称：Antiproliferative activity against human A549 cells after 72 hrs by CellTiter-Glo lum... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4154442

实验名称：Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase at 20 uM... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4154451

实验名称：Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2-phase at 20 uM... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4154452

共29条，当前第1页，共3页

1

2

3

BRD4-IN-4英文别名

• 1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one
• 1-Ethyl-6-(1-pyrrolidinylsulfonyl)benzo[cd]indol-2(1H)-one
• 1-Ethyl-6-(pyrrolidine-1-sulfonyl)-1H-benzo[cd]indol-2-one