2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-iodo

• 常用名: 2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-iodo
• 英文名: 2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-iodo
• CAS号: 3052-06-0
• 分子量: 370.10
• 密度: 2.27g/cm3
• 沸点: N/A
• 分子式: C₉H₁₁IN₂O₆
• 熔点: N/A
• 闪点: N/A

用途

1-β-D-阿拉伯呋喃糖基-5-碘尿嘧啶是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 英文名: 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione

生物活性

• 描述: 1-β-D-阿拉伯呋喃糖基-5-碘尿嘧啶是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

• 密度: 2.27g/cm3
• 分子式: C₉H₁₁IN₂O₆
• 分子量: 370.10
• 精确质量: 369.96600
• PSA: 124.78000
• InChIKey: RKSLVDIXBGWPIS-MNCSTQPFSA-N
• SMILES: O=c1[nH]c(=O)n(C2OC(CO)C(O)C2O)cc1I
• 折射率: 1.748

靶点实验

查看更多实验

实验名称：Antiviral activity against HSV1 2931 infected in African green monkey Vero cells asse... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL3232070

实验名称：Inhibition of Herpesvirus 1 pyrimidine 2'-deoxyribonucleoside kinase by double recipr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3254538

实验名称：Antiviral activity against HSV1 2931 infected in African green monkey Vero cells asse... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL3232069

实验名称：Antiviral activity against HSV1 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL3254537

实验名称：Cytotoxicity against mouse P815 cells assessed as growth inhibition after 96 hrs 来源：ChEMBL 靶标：P815 External Id：CHEMBL3232063

实验名称：Antiviral activity against HSV1 2931 infected in African green monkey Vero cells asse... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL3232066

实验名称：Antiviral activity against HSV1 2931 infected in African green monkey Vero cells asse... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL3232065

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL3231444

实验名称：Cytotoxicity against mouse L5178Y cells assessed as growth inhibition after 96 hrs 来源：ChEMBL 靶标：L5178Y External Id：CHEMBL3232068

实验名称：Cytotoxicity against mouse L1210 cells at 400 uM after 1 day 来源：ChEMBL 靶标：L1210 External Id：CHEMBL3254536

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英文别名

• 5-Iodoarabinouridine