4,5,6,7-四氯茚满-1,3-二酮

• 常用名: 4,5,6,7-四氯茚满-1,3-二酮
• 英文名: TCID
• CAS号: 30675-13-9
• 分子量: 283.923
• 密度: 1.8±0.1 g/cm3
• 沸点: 448.1±45.0 °C at 760 mmHg
• 分子式: C₉H₂Cl₄O₂
• 熔点: 218-220ºC
• 闪点: 188.8±29.3 °C
• 符号: GHS07
• 信号词: Warning

4,5,6,7-四氯茚满-1,3-二酮用途

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂,IC50 为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。

4,5,6,7-四氯茚满-1,3-二酮名称

• 中文名: 4,5,6,7-四氯茚满-1,3-二酮
• 英文名: 4,5,6,7-tetrachloroindene-1,3-dione

4,5,6,7-四氯茚满-1,3-二酮生物活性

• 描述: TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂,IC50 为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 细胞周期/DNA损伤 >> 去泛素化酶
• 靶点实验:

  IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1]

• 体外研究: TCID(4,5,6,7-四氯吲哚-1,3-二酮；化合物11)以75μM的IC50抑制UCH-L1[1]。TCID(10μM；1,2小时)减少脑干和脊髓原代神经元中甘氨酸转运体GlyT2的泛素化[2]。
• 参考文献:

  [1]. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46.

  [2]. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863.

4,5,6,7-四氯茚满-1,3-二酮物理化学性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 448.1±45.0 °C at 760 mmHg
• 熔点: 218-220ºC
• 分子式: C₉H₂Cl₄O₂
• 分子量: 283.923
• 闪点: 188.8±29.3 °C
• 精确质量: 281.880890
• PSA: 34.14000
• LogP: 3.94
• InChIKey: IDLAOWFFKWRNHB-UHFFFAOYSA-N
• SMILES: O=C1CC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c21
• 外观性状: 粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.652
• 储存条件: -20℃

4,5,6,7-四氯茚满-1,3-二酮MSDS

4,5,6,7-四氯茚满-1,3-二酮MSDS英文版

4,5,6,7-四氯茚满-1,3-二酮安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2914700090

4,5,6,7-四氯茚满-1,3-二酮海关

• 海关编码: 2914700090
• 中文概述: 2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

4,5,6,7-四氯茚满-1,3-二酮靶点实验

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实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

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实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using DABCYL-KTS... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5147544

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4,5,6,7-四氯茚满-1,3-二酮英文别名

• 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione
• Ubiquitin C-Terminal Hydrolase L3 Inhibitor
• Ubiquitin Thiolesterase L3 Inhibitor
• 4,5,6,7-Tetrachloroindan-1,3-dione
• 4,5,6,7-Tetrachlorindan-1,3-dion
• 4,5,6,7-Tetrachlorphenyl-1,3-indandion
• 4,5,6,7-tetrachloroindane-1,3-dione
• UCH-L3 Inhibitor
• TCID
• Ubiquitin C-Terminal Esterase L3 Inhibitor