ABC-1

• 常用名: ABC-1
• 英文名: ABC-1
• CAS号: 309735-05-5
• 分子量: 284.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₆N₂OS
• 熔点: N/A
• 闪点: N/A

ABC-1用途

ABC-1是一种磷酸化类似物,是一种潜在的抗新城疫病毒(NDV)的抗病毒药物。ABC-1具有强大的抗病毒活性[1][2]。

ABC-1名称

• 英文名: ABC-1

ABC-1生物活性

• 描述: ABC-1是一种磷酸化类似物,是一种潜在的抗新城疫病毒(NDV)的抗病毒药物。ABC-1具有强大的抗病毒活性[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
• 体外研究: ABC-1(175和350μM；96小时)能有效抑制细胞病变效应(CPE)[1]。细胞毒性试验[1]细胞系：DF-1细胞浓度：175和350μM培养时间：96小时结果：抑制细胞病变效应(CPE)。
• 体内研究: 与NDV对照动物相比,ABC-1(2 mg/kg；口服)可减少肝脏中的共定位细胞和肺组织中的clara细胞[2]。动物模型：鸡(NDV处理)[2]剂量：2 mg/kg给药：口服结果：与NDV对照动物相比,肝脏中的共定位细胞和肺组织中的clara细胞减少。
• 参考文献:

  [1]. K A S, et al. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016;180(2):361-381.

  [2]. Suresh KA, et al. Phosphorylated abacavir analogue (ABC-1) has ameliorative action against Newcastle disease virus induced pathogenesis in chicken. Biotechnol Appl Biochem. 2019;66(6):977-989.

ABC-1物理化学性质

• 分子式: C₁₆H₁₆N₂OS
• 分子量: 284.38
• InChIKey: HRUYBRGMRSNLNW-UHFFFAOYSA-N
• SMILES: COc1ccc2nc(SCc3ccc(C)cc3)[nH]c2c1
• 储存条件: -20°C

ABC-1靶点实验

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实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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