ABC-1

Modify Date: 2024-01-14 20:20:48

ABC-1 Structure
ABC-1 structure
Common Name ABC-1
CAS Number 309735-05-5 Molecular Weight 284.38
Density N/A Boiling Point N/A
Molecular Formula C16H16N2OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ABC-1


ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity[1][2].

 Names

Name ABC-1

 ABC-1 Biological Activity

Description ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity[1][2].
Related Catalog
In Vitro ABC-1 (175 and 350 μM; 96 hours) potently inhibits Cytopathic effect (CPE) [1]. Cell Cytotoxicity Assay[1] Cell Line: DF-1 cells Concentration: 175 and 350 μM Incubation Time: 96 hours Result: Inhibits Cytopathic effect (CPE).
In Vivo ABC-1 (2 mg/kg; Oral) reduces colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals[2]. Animal Model: Chickens (NDV treated) [2] Dosage: 2 mg/kg Administration: Oral Result: Reduced colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals.
References

[1]. K A S, et al. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016;180(2):361-381.

[2]. Suresh KA, et al. Phosphorylated abacavir analogue (ABC-1) has ameliorative action against Newcastle disease virus induced pathogenesis in chicken. Biotechnol Appl Biochem. 2019;66(6):977-989.

 Chemical & Physical Properties

Molecular Formula C16H16N2OS
Molecular Weight 284.38
Storage condition -20°C
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