KL001

• 常用名: KL001
• 英文名: KL 001
• CAS号: 309928-48-1
• 分子量: 398.475
• 密度: 1.3±0.1 g/cm3
• 沸点: 578.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂N₂O₄S
• 熔点: N/A
• 闪点: 303.4±32.9 °C
• 符号: GHS07
• 信号词: Warning

KL001用途

KL001 是一种隐花色素蛋白 (CRY) 稳定剂,可与 CRY1 和 CRY2 特异性相互作用。 KL001 防止泛素依赖性 CRY 降解,从而延长了昼夜节律周期。KL001 具有控制空腹激素诱导的糖异生的潜力。

KL001名称

• 英文名: kl001

KL001生物活性

• 描述: KL001 是一种隐花色素蛋白 (CRY) 稳定剂,可与 CRY1 和 CRY2 特异性相互作用。 KL001 防止泛素依赖性 CRY 降解,从而延长了昼夜节律周期。KL001 具有控制空腹激素诱导的糖异生的潜力。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体外研究: KL001(0.03-71μM)在含有Bmal1-dLuc或Per2-dLuc的稳定U2OS报告细胞系中引起昼夜节律延长和振幅降低[1]。KL001(2-8μM；18 h)以剂量依赖性方式抑制胰高血糖素依赖性Pck1和G6pc基因的诱导,而不影响它们在小鼠原代肝细胞中的基础表达[1]。
• 参考文献:

  [1]. Hirota T, et, al. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.

  [2]. Kelleher FC, et, al. Circadian molecular clocks and cancer. Cancer Lett. 2014 Jan 1;342(1):9-18.

KL001物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 578.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂N₂O₄S
• 分子量: 398.475
• 闪点: 303.4±32.9 °C
• 精确质量: 398.130035
• PSA: 84.06000
• LogP: 4.70
• InChIKey: OQAFDLPAPSSOHY-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)N(Cc1ccco1)CC(O)Cn1c2ccccc2c2ccccc21
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.642
• 储存条件: 2-8°C

KL001安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport

KL001靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-MM1R-m4-1

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KL001英文别名

• N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furylmethyl)methanesulfonamide
• N-(3-Carbazol-9-yl-2-hydroxy-propyl)-N-furan-2-ylmethyl-methanesulfonamide