DSHN

• 常用名: DSHN
• 英文名: DSHN
• CAS号: 313952-63-5
• 分子量: 323.36
• 密度: 1.4±0.1 g/cm3
• 沸点: 519.7±60.0 °C at 760 mmHg
• 分子式: C₁₅H₁₇NO₅S
• 熔点: N/A
• 闪点: 268.1±32.9 °C

DSHN用途

DSHN 是一种有效的小异二聚体伴侣 (SHP) 激活剂。DSHN 通过抑制 Ccl2 启动子活性的 p65 激活来抑制 Ccl2 表达和分泌。DSHN 可用于癌症研究。

DSHN名称

• 英文名: DSHN

DSHN生物活性

• 描述: DSHN 是一种有效的小异二聚体伴侣 (SHP) 激活剂。DSHN 通过抑制 Ccl2 启动子活性的 p65 激活来抑制 Ccl2 表达和分泌。DSHN 可用于癌症研究。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Yang Z, et, al. A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2. Mol Cancer Ther. 2016 Oct;15(10):2294-2301.

DSHN物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 519.7±60.0 °C at 760 mmHg
• 分子式: C₁₅H₁₇NO₅S
• 分子量: 323.36
• 闪点: 268.1±32.9 °C
• 精确质量: 323.082733
• LogP: 3.49
• InChIKey: DJLPAJSKAPXAHV-UHFFFAOYSA-N
• SMILES: CCN(CC)S(=O)(=O)c1cccc2cc(C(=O)O)c(O)cc12
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.634

DSHN靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

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DSHN英文别名

• 5-[(Diethylamino)sulfonyl]-3-hydroxy-2-naphthalenecarboxylic acid
• DSHN
• 5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid
• 5-(Diethylsulfamoyl)-3-hydroxy-2-naphthoic acid
• 5-(DIETHYLSULFAMOYL)-3-HYDROXYNAPHTHALENE-2-CARBOXYLIC ACID