(1R,2S,5S,6S)-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID, 2-AMINO-6-FLUORO-4-OXO

• 常用名: (1R,2S,5S,6S)-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID, 2-AMINO-6-FLUORO-4-OXO
• 英文名: (1R,2S,5S,6S)-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID, 2-AMINO-6-FLUORO-4-OXO
• CAS号: 321963-33-1
• 分子量: 217.151
• 密度: 1.8±0.1 g/cm3
• 沸点: 438.4±45.0 °C at 760 mmHg
• 分子式: C₈H₈FNO₅
• 熔点: N/A
• 闪点: 218.9±28.7 °C

用途

MGS0028 是一种选择性代谢型谷氨酸 2/3 (mGlu2/3) 受体激动剂。MGS0028 可用于精神疾病研究。

名称

• 英文名: MGS-0028

生物活性

• 描述: MGS0028 是一种选择性代谢型谷氨酸 2/3 (mGlu2/3) 受体激动剂。MGS0028 可用于精神疾病研究。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  mGlu2 Receptor

  mGluR3R

• 参考文献:

  [1]. Yukio Ago, et al. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide. Behav Pharmacol. 2013 Feb;24(1):74-7.

物理化学性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 438.4±45.0 °C at 760 mmHg
• 分子式: C₈H₈FNO₅
• 分子量: 217.151
• 闪点: 218.9±28.7 °C
• 精确质量: 217.038651
• LogP: -1.98
• InChIKey: KFAGJPNFERWZJA-JKBXLQNXSA-N
• SMILES: NC1(C(=O)O)CC(=O)C2C1C2(F)C(=O)O
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.613

靶点实验

查看更多实验

实验名称：Tested for mGluR agonist activity by measuring the PCP induced hyperactivity in rats ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL801323

实验名称：Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 3 External Id：CHEMBL713037

实验名称：Phosphoinositide hydrolysis by human Metabotropic glutamate receptor 1 (mGluR1) expre... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL709770

实验名称：Agonist potency against cloned Metabotropic glutamate receptor 3; NT is Not Tested. 来源：ChEMBL 靶标：Metabotropic glutamate receptor 3 External Id：CHEMBL713036

实验名称：Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 2 External Id：CHEMBL713613

实验名称：Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 2 External Id：CHEMBL718223

实验名称：Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 2 External Id：CHEMBL718227

实验名称：Inhibition of c-AMP by human Metabotropic glutamate receptor 8 (mGluR8) expressed in ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 8 External Id：CHEMBL709835

实验名称：Tested for % inhibition of PCP induced head-weavings in rats at 0.03 ug/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL882237

实验名称：Tested for % inhibition of PCP induced head-weavings in rats at 0.1 ug/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL793190

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英文别名

• (1R,2S,5S,6S)-2-Amino-6-fluoro-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
• MGS-0028
• YMS878LR7I