L67

• 常用名: L67
• 英文名: L67
• CAS号: 325970-71-6
• 分子量: 486.115
• 密度: 1.8±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₆H₁₄Br₂N₄O₄
• 熔点: N/A
• 闪点: N/A

L67用途

L67是一种新型的竞争性 DNA连接酶抑制剂,抑制DNA连接酶I和III, IC50为10μM。

L67名称

• 中文名: L67
• 英文名: Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

L67生物活性

• 描述: L67是一种新型的竞争性 DNA连接酶抑制剂,抑制DNA连接酶I和III, IC50为10μM。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 癌症
• 参考文献:

  [1]. Zhong S, et al. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-4562.

  [2]. Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-3177.

L67物理化学性质

• 密度: 1.8±0.1 g/cm3
• 分子式: C₁₆H₁₄Br₂N₄O₄
• 分子量: 486.115
• 精确质量: 483.938171
• LogP: 6.23
• InChIKey: KFEPVFJQVOMODD-UHFFFAOYSA-N
• SMILES: Cc1c(Br)cc(NCC(=O)NN=Cc2cc([N+](=O)[O-])ccc2O)cc1Br
• 折射率: 1.681
• 储存条件: 2-8℃

L67靶点实验

查看更多实验

实验名称：Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinati... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_P

实验名称：Drug screen in ICB984 medulloblastoma cells to determine synergistic drug combination... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_ICB984_MB

实验名称：Drug screen in HDN33 neuroblastoma cells to determine synergistic drug combinations t... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HDN33

实验名称：Drug screen in HD-MB03 medulloblastoma cells to determine synergistic drug combinatio... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HD-MB03

实验名称：Drug screen in CRL2098 osteosarcoma cells to determine synergistic drug combinations ... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_CRL2098

实验名称：Drug screen in CRL1545 osteosarcoma cells to determine synergistic drug combinations ... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_CRL1545

实验名称：Antiproliferative activity against human HCT116 cells relative to control 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4337612

实验名称：Inhibition of human DNA ligase 1 at 100 uM using nicked DNA as substrate by high-thro... 来源：ChEMBL 靶标：DNA ligase 1 External Id：CHEMBL4337611

实验名称：Drug screen in LFS_MB_2R medulloblastoma cells to determine synergistic drug combinat... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_2R

实验名称：Drug screen in UWB1.289 ovarian carcinoma cells to determine synergistic drug combina... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_UWB1.289

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L67英文别名

• 2-[(3,5-Dibromo-4-methylphenyl)amino]-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylene]acetohydrazide
• L67