3-(吡啶-2-基)-5-(3-氟-5-氰基苯基)-1,2,4-噁二唑

• 常用名: 3-(吡啶-2-基)-5-(3-氟-5-氰基苯基)-1,2,4-噁二唑
• 英文名: VU 0285683
• CAS号: 327056-22-4
• 分子量: 266.23000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₇FN₄O
• 熔点: N/A
• 闪点: N/A

用途

VU0285683 是一种选择性 mGluR5 正变构调节剂 (PAM)。VU0285683 在啮齿动物焦虑模型中具有抗焦虑样活性。

名称

• 中文名: 3-(吡啶-2-基)-5-(3-氟-5-氰基苯基)-1,2,4-噁二唑
• 英文名: 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

生物活性

• 描述: VU0285683 是一种选择性 mGluR5 正变构调节剂 (PAM)。VU0285683 在啮齿动物焦虑模型中具有抗焦虑样活性。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

物理化学性质

• 分子式: C₁₄H₇FN₄O
• 分子量: 266.23000
• 精确质量: 266.06000
• PSA: 75.60000
• LogP: 2.80938
• InChIKey: GELAFISMURFRCA-UHFFFAOYSA-N
• SMILES: N#Cc1cc(F)cc(-c2nc(-c3ccccn3)no2)c1

靶点实验

查看更多实验

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实验名称：Intrinsic clearance in human liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2168559

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