A1AR antagonist 6

• 常用名: A1AR antagonist 6
• 英文名: A1AR antagonist 6
• CAS号: 329693-22-3
• 分子量: 293.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅N₃O₂
• 熔点: N/A
• 闪点: N/A

A1AR antagonist 6用途

A1AR拮抗剂6(化合物15)是一种有效的选择性A1AR(A1腺苷受体)拮抗剂,pIC50为6.38,pKi为7.13【1】。

A1AR antagonist 6名称

• 英文名: A1AR antagonist 6

A1AR antagonist 6生物活性

• 描述: A1AR拮抗剂6(化合物15)是一种有效的选择性A1AR(A1腺苷受体)拮抗剂,pIC50为6.38,pKi为7.13【1】。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
• 靶点实验:

  hA1AR:7.13 (pKi)

  hA2AAR:<4 (pKi)

• 参考文献:

  [1]. Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.

A1AR antagonist 6物理化学性质

• 分子式: C₁₇H₁₅N₃O₂
• 分子量: 293.32

A1AR antagonist 6靶点实验

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实验名称：Displacement of [3H]DPCPX from human A1AR expressed in CHO cells incubated for 50 min... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL4417608

实验名称：Cell survival assay for modulators of telomere damage signalling 来源：15378 靶标：N/A External Id：TELO_02

实验名称：Selectivity index, ratio of Ki for human A1AR expressed in CHO cells to Ki for human ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4417609

实验名称：Inhibitors of CDC25B-CDK2/CyclinA interaction 来源：Center for Chemical Genomics, University of Michigan External Id：MScreen:TargetID_600

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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