TC HSD 21

• 常用名: TC HSD 21
• 英文名: TC HSD 21
• CAS号: 330203-01-5
• 分子量: 422.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₂BrNO₃S₂
• 熔点: N/A
• 闪点: N/A

TC HSD 21用途

TC HSD 21 是一种有效的 17β 羟甾类脱氢酶 3 型 (17β-HSD3) 抑制剂,IC50 值为 14 nM,TC HSD 21 对 17β-HSD 同工酶和核受体具有良好的选择性。

TC HSD 21名称

• 中文名: TC HSD 21
• 英文名: 5-(3-bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one

TC HSD 21生物活性

• 描述: TC HSD 21 是一种有效的 17β 羟甾类脱氢酶 3 型 (17β-HSD3) 抑制剂,IC50 值为 14 nM,TC HSD 21 对 17β-HSD 同工酶和核受体具有良好的选择性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 14 nM (17β-HSD3)[1]

• 参考文献:

  [1]. Harada K,et al. Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):504-7.

TC HSD 21物理化学性质

• 分子式: C₁₇H₁₂BrNO₃S₂
• 分子量: 422.32
• 精确质量: 420.94400
• PSA: 107.16000
• LogP: 4.63410
• InChIKey: HEFKAUYVLSGPGC-DHDCSXOGSA-N
• SMILES: COc1ccc(N2C(=O)C(=Cc3ccc(O)c(Br)c3)SC2=S)cc1
• 储存条件: 2-8℃

TC HSD 21靶点实验

查看更多实验

实验名称：Antagonist activity at glucocorticoid receptor by transcriptional reporter gene assay 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL1937972

实验名称：Agonist activity at glucocorticoid receptor by transcriptional reporter gene assay 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL1937971

实验名称：Inhibition of human 17beta-HSD3 activity expressed in HeLa cells assessed as conversi... 来源：ChEMBL 靶标：17-beta-hydroxysteroid dehydrogenase type 3 External Id：CHEMBL1937973

实验名称：Antagonist activity at ERalpha by transcriptional reporter gene assay 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL1937970

实验名称：Agonist activity at ERalpha by transcriptional reporter gene assay 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL1937969

实验名称：Inhibition of 17beta-HSD1 expressed in HeLa cells assessed as conversion of estrone i... 来源：ChEMBL 靶标：17-beta-hydroxysteroid dehydrogenase type 1 External Id：CHEMBL1937892

实验名称：Antagonist activity at human GR receptor expressed in human HeLa cells assessed as in... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2021217

实验名称：Agonist activity at androgen receptor by transcriptional reporter gene assay 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL1937894

实验名称：Antagonist activity at human androgen receptor expressed in human HeLa cells assessed... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL2021215

实验名称：Inhibition of 17beta-HSD2 expressed in HeLa cells assessed as conversion of estrone i... 来源：ChEMBL 靶标：17-beta-hydroxysteroid dehydrogenase type 2 External Id：CHEMBL1937893

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