帕拉米韦

• 常用名: 帕拉米韦
• 英文名: peramivir
• CAS号: 330600-85-6
• 分子量: 328.407
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₅H₂₈N₄O₄
• 熔点: N/A
• 闪点: N/A

帕拉米韦用途

Peramivir (RWJ 270201; Rapiacta; BCX 1812)是过渡态类似物,是高活性的流感病毒神经氨酸酶抑制剂,IC50中位值为0.09 nM。

帕拉米韦名称

• 中文名: 帕拉米韦
• 英文名: peramivir

帕拉米韦生物活性

• 描述: Peramivir (RWJ 270201; Rapiacta; BCX 1812)是过渡态类似物,是高活性的流感病毒神经氨酸酶抑制剂,IC50中位值为0.09 nM。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 参考文献:

  [1]. Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection By Sugaya, Norio; Kohno, Shigeru; Ishibashi, Toru; Wajima, Toshihiro; Takahashi, Takao From Antimicrobial Agents and Chemothera

  [2]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM. Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09. PLoS One. 2012;7(6):e40261.

  [3]. Sakata H. Clinical efficiency in children treated with intravenous drip infusion of peramivir.Jpn J Antibiot. 2011 Dec;64(6):383-7.

  [4]. Abed Y, Pizzorno A, Boivin G. Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation. Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80.

  [5]. Hikita T, Hikita H, Hikita F, Hikita N, Hikita S. Clinical effectiveness of peramivir in comparison with other neuraminidase inhibitors in pediatric influenza patients.Int J Pediatr. 2012;2012:834181.

帕拉米韦物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₁₅H₂₈N₄O₄
• 分子量: 328.407
• 精确质量: 328.211060
• PSA: 151.03000
• LogP: -1.37
• InChIKey: XRQDFNLINLXZLB-UHFFFAOYSA-N
• SMILES: CCC(CC)C(NC(C)=O)C1C(N=C(N)N)CC(C(=O)O)C1O
• 折射率: 1.614
• 储存条件: 2-8℃

帕拉米韦英文别名

• (1S,2S,3R,4R)-3-[(1S)-1-Acetamido-2-ethylbutyl]-4-carbamimidamido-2-hydroxycyclopentanecarboxylic acid
• Rapiacta
• (1S,2S,3R,4R)-3-((S)-1-Acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid
• Peramivir
• (1S,2S,3R,4R)-3-(1-Acetamido-2-ethylbutyl)-4-carbamimidamido-2-hydroxycyclopentanecarboxylic acid
• Rapivab
• Bcx-1812
• UNII:IDL9Q29886
• PeraMiviv
• (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic Acid
• Peramiflu
• Peramivir(BCX-1812)