VU0029251

• 常用名: VU0029251
• 英文名: VU0029251
• CAS号: 330819-85-7
• 分子量: 237.344
• 密度: 1.5±0.1 g/cm3
• 沸点: 501.7±60.0 °C at 760 mmHg
• 分子式: C₁₀H₁₁N₃S₂
• 熔点: N/A
• 闪点: 257.2±32.9 °C

VU0029251用途

VU0029251 是一种 mGluR5 部分拮抗剂(Ki: 1.07 μM)。VU0029251 抑制表达大鼠 mGluR5 的 HEK293 细胞膜中谷氨酸诱导的钙动员 (IC50: 1.7 μM)。

VU0029251名称

• 英文名: VU0029251

VU0029251生物活性

• 描述: VU0029251 是一种 mGluR5 部分拮抗剂(Ki: 1.07 μM)。VU0029251 抑制表达大鼠 mGluR5 的 HEK293 细胞膜中谷氨酸诱导的钙动员 (IC50: 1.7 μM)。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  mGluR5[1].

• 参考文献:

  [1]. Rodriguez, A.L., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol. 78(6), 1105-1123 (2010).

VU0029251物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 501.7±60.0 °C at 760 mmHg
• 分子式: C₁₀H₁₁N₃S₂
• 分子量: 237.344
• 闪点: 257.2±32.9 °C
• 精确质量: 237.039444
• LogP: 4.31
• InChIKey: WDDBZCKBRCTSOZ-UHFFFAOYSA-N
• SMILES: CSc1nc(N)c2c3c(sc2n1)CCC3
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.745

VU0029251靶点实验

查看更多实验

实验名称：qHTS screening for TAG (triacylglycerol) accumulators in algae 来源：11812 靶标：N/A External Id：FATTTLab-Algae-Lipid

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实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Alphascreen assay for small molecules abrogating mHTT-CaM Interaction 来源：24983 靶标：Huntingtin External Id：KUHTS-Muma KU-CaM-Htt INH-01

实验名称：Inhibition of LIMK1 using cofilin-2 as substrate after 60 mins by Kinase-Glo assay 来源：ChEMBL 靶标：LIM domain kinase 1 External Id：CHEMBL1839797

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

实验名称：Inhibition of LIMK1 using cofilin-2 as substrate after 60 mins by TR-FRET assay 来源：ChEMBL 靶标：LIM domain kinase 1 External Id：CHEMBL1839798

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VU0029251英文别名

• MFCD00698485
• VU0029251
• 2-(Methylsulfanyl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
• 6,7-dihydro-2-(methylthio)-5h-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine