KP-23172

• 常用名: KP-23172
• 英文名: KP-23172
• CAS号: 331253-86-2
• 分子量: 224.17800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₄N₆O
• 熔点: N/A
• 闪点: N/A

KP-23172用途

KP-23172 是一种 PI3-K/Akt 通道抑制剂,详见专利 US7196083。

KP-23172名称

• 中文名: PDK1/Akt/Flt Dual Pathway抑制剂
• 英文名: 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one

KP-23172生物活性

• 描述: KP-23172 是一种 PI3-K/Akt 通道抑制剂,详见专利 US7196083。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
• 靶点实验:

  PI3-K

  Akt

• 体外研究: KP-23172(10μM；60分钟)显著增强NRP诱导的细胞凋亡[1]。
• 参考文献:

  [1]. Xi RG, et al. Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells. Acta Pharmacol Sin. 2008 Mar;29(3):355-63.

KP-23172物理化学性质

• 分子式: C₁₀H₄N₆O
• 分子量: 224.17800
• 精确质量: 224.04500
• PSA: 85.93000
• LogP: 0.12570
• InChIKey: DPANHMGWPXVBQI-UHFFFAOYSA-N
• SMILES: O=C1c2ccccc2-c2nc3nnnn3nc21
• 储存条件: -20℃

KP-23172安全信息

KP-23172靶点实验

查看更多实验

实验名称：NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction ... 来源：ChEMBL 靶标：Plasmodium yoelii External Id：CHEMBL1789905

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

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KP-23172英文别名

• p-Dimethylaminophenyl-isopropyl-sulfid
• PDK1/Akt/Flt Dual Pathway Inhibitor
• Benzenamine,N,N-dimethyl-4-[(1-methylethyl)thio]