CFM-4

• 常用名: CFM-4
• 英文名: CFM-4
• CAS号: 331458-02-7
• 分子量: 405.90
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₆ClN₃OS
• 熔点: N/A
• 闪点: N/A

CFM-4用途

CFM-4是一种有效的小分子CARP-1/APC-2结合拮抗剂。CFM-4阻止CARP-1与APC-2结合,导致G2M细胞周期停滞,并诱导IC50范围为10-15μM的细胞凋亡。CFM-4还抑制耐药人类乳腺癌细胞的生长【1】。

CFM-4名称

• 英文名: 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro[indoline-3,2'-[1.3.4]thiadiazol]-2-one

CFM-4生物活性

• 描述: CFM-4是一种有效的小分子CARP-1/APC-2结合拮抗剂。CFM-4阻止CARP-1与APC-2结合,导致G2M细胞周期停滞,并诱导IC50范围为10-15μM的细胞凋亡。CFM-4还抑制耐药人类乳腺癌细胞的生长【1】。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017.

CFM-4物理化学性质

• 分子式: C₂₂H₁₆ClN₃OS
• 分子量: 405.90
• 精确质量: 405.07000
• PSA: 70.00000
• LogP: 4.56720
• InChIKey: PMADITKBVODKSF-UHFFFAOYSA-N
• SMILES: O=C1N(Cc2ccccc2Cl)c2ccccc2C12NN=C(c1ccccc1)S2

CFM-4靶点实验

查看更多实验

实验名称：Cell survival assay for modulators of telomere damage signalling 来源：15378 靶标：N/A External Id：TELO_02

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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CFM-4英文别名

• CFM-4
• L-703,664 succinate