5-碘靛红-3'-单肟

• 常用名: 5-碘靛红-3'-单肟
• 英文名: 5-Iodo-indirubin-3'-monoxime
• CAS号: 331467-03-9
• 分子量: 403.17
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₀IN₃O₂
• 熔点: N/A
• 闪点: N/A

5-碘靛红-3'-单肟用途

5-Iodo-indirubin-3'-monoxime 是一种有效的 GSK-3β,CDK5/P25 和 CDK1/cyclin B 抑制剂,与 ATP 竞争性地结合酶的催化位点,IC50 值分别为 9,20 和 25 nM。

5-碘靛红-3'-单肟名称

• 中文名: 5-碘靛红-3'-单肟
• 英文名: 5-Iodo-indirubin-3'-monoxime

5-碘靛红-3'-单肟生物活性

• 描述: 5-Iodo-indirubin-3'-monoxime 是一种有效的 GSK-3β,CDK5/P25 和 CDK1/cyclin B 抑制剂,与 ATP 竞争性地结合酶的催化位点,IC50 值分别为 9,20 和 25 nM。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GSK-3
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> CDK
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
• 靶点实验:

  GSK-3β:9 nM (IC50)

  Cdk5/p25:20 nM (IC50)

  Cdk1/cyclin B:25 nM (IC50)

• 参考文献:

  [1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

5-碘靛红-3'-单肟物理化学性质

• 分子式: C₁₆H₁₀IN₃O₂
• 分子量: 403.17
• InChIKey: WCCYEJYTLNWYCC-UHFFFAOYSA-N
• SMILES: O=Nc1c(-c2c(O)[nH]c3ccc(I)cc23)[nH]c2ccccc12
• 储存条件: -20°C，密封，干燥

5-碘靛红-3'-单肟靶点实验

查看更多实验

实验名称：Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 24 hr... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4044680

实验名称：Inhibition of human GSK3-beta 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL1034478

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

实验名称：Delta TM value showing the stabilisation of CDK2 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL3430798

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