5-Iodo-indirubin-3'-monoxime

Modify Date: 2025-09-26 22:43:05

5-Iodo-indirubin-3'-monoxime Structure
5-Iodo-indirubin-3'-monoxime structure
 Common Name 5-Iodo-indirubin-3'-monoxime
CAS Number 331467-03-9 Molecular Weight 403.17
Density N/A Boiling Point N/A
Molecular Formula C16H10IN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Iodo-indirubin-3'-monoxime


5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

 Names

Name 5-Iodo-indirubin-3'-monoxime

 5-Iodo-indirubin-3'-monoxime Biological Activity

Description 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].
Related Catalog
Target

GSK-3β:9 nM (IC50)

Cdk5/p25:20 nM (IC50)

Cdk1/cyclin B:25 nM (IC50)

References

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

 Chemical & Physical Properties

Molecular Formula C16H10IN3O2
Molecular Weight 403.17
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