DHFR-IN-2

• 常用名: DHFR-IN-2
• 英文名: DHFR-IN-2
• CAS号: 331942-46-2
• 分子量: 227.26
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₃NO₂
• 熔点: N/A
• 闪点: N/A

DHFR-IN-2用途

DHFR-IN-2(化合物4e)是MtDHFR(结核分枝杆菌二氢叶酸还原酶)的有效且无竞争性的抑制剂,IC50为7μM。DHFR-IN-2可用于结核(TB)研究[1]。

DHFR-IN-2名称

• 英文名: DHFR-IN-2

DHFR-IN-2生物活性

• 描述: DHFR-IN-2(化合物4e)是MtDHFR(结核分枝杆菌二氢叶酸还原酶)的有效且无竞争性的抑制剂,IC50为7μM。DHFR-IN-2可用于结核(TB)研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> 叶酸
• 靶点实验:

  IC50: 7 ± 0.13 μM (MtDHFR)[1]

• 参考文献:

  [1]. Kronenberger T,et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors. Bioorg Med Chem. 2020 Aug 1;28(15):115600.

DHFR-IN-2物理化学性质

• 分子式: C₁₄H₁₃NO₂
• 分子量: 227.26
• InChIKey: OYVGWXUICDQOKV-UHFFFAOYSA-N
• SMILES: O=C(O)c1cccc(CNc2ccccc2)c1

DHFR-IN-2靶点实验

查看更多实验

实验名称：Inhibition of recombinant Mycobacterium tuberculosis DHFR expressed in Escherichia co... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL4625598

实验名称：Uncompetitive inhibition of Mycobacterium tuberculosis DHFR assessed as varying Vmax ... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL4625600

实验名称：Uncompetitive inhibition of Mycobacterium tuberculosis DHFR assessed as constant Km u... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL4625599

实验名称：Potency index, ratio of trimethoprim IC50 to test compound IC50 for recombinant Mycob... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL4625602

实验名称：Potency index, ratio of MB872 IC50 to test compound IC50 for recombinant Mycobacteriu... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL4625601

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