去氧土大黄苷元

• 常用名: 去氧土大黄苷元
• 英文名: Desoxyrhapontigenin
• CAS号: 33626-08-3
• 分子量: 242.270
• 密度: 1.252
• 沸点: 446.5±14.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄O₃
• 熔点: N/A
• 闪点: 223.8±20.1 °C

去氧土大黄苷元用途

4'-Methoxyresveratrol (4'-O-Methylresveratrol) 是一种来源于双翅目植物的多酚类化合物,具有抗雄激素、抗真菌和抗炎症活性。4 ' –Methoxyresveratrol 能通过抑制 RAGE- 介导的 MAPK/NF-κB 信号通路和激活 NLRP3 炎性体来缓解 AGE- 诱导的炎症。

去氧土大黄苷元名称

• 中文名: 白藜芦醇-4'-甲醚
• 英文名: 4'-Methoxyresveratrol
• 中文别名: (E)-3,5-二羟基-4'-甲氧基二苯乙烯 | 白藜芦醇-4’-甲醚 | 3,5-二羟基-4'-甲氧基二苯乙烯 | 3-[(1E)-2-(4-甲氧基苯基)乙烯基]-1,5-苯二酚

去氧土大黄苷元生物活性

• 描述: 4'-Methoxyresveratrol (4'-O-Methylresveratrol) 是一种来源于双翅目植物的多酚类化合物,具有抗雄激素、抗真菌和抗炎症活性。4 ' –Methoxyresveratrol 能通过抑制 RAGE- 介导的 MAPK/NF-κB 信号通路和激活 NLRP3 炎性体来缓解 AGE- 诱导的炎症。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Yu W, et al. 4'-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway. Molecules. 2018 Jun 14;23(6).

去氧土大黄苷元物理化学性质

• 密度: 1.252
• 沸点: 446.5±14.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄O₃
• 分子量: 242.270
• 闪点: 223.8±20.1 °C
• 精确质量: 242.094299
• PSA: 49.69000
• LogP: 3.62
• InChIKey: IHVRWFJGOIWMGC-NSCUHMNNSA-N
• SMILES: COc1ccc(C=Cc2cc(O)cc(O)c2)cc1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.692
• 储存条件: 2-8°C

去氧土大黄苷元安全信息

• 危害码 (欧洲): Xi

去氧土大黄苷元靶点实验

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实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1 External Id：IucA Pilot Assay Spectrum Library

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation a... 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL1248459

实验名称：Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation as... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL1248458

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：In vitro growth inhibition of KM20L2 cell line. 来源：ChEMBL 靶标：KM-20L2 External Id：CHEMBL704498

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去氧土大黄苷元英文别名

• trans-3,5-dihydroxy-4'-methoxystlibene
• 3,5-dihydroxy-4'-methoxy-trans-stilbene
• 3,4-methylenedioxybenzaldehyde oxime
• (E)-3,4-Methylenedioxybenzaldoxime
• 4-Methoxyresveratrol
• (E)-5-(4-methoxystyryl)benzene-1,3-diol
• Oxirane,2,3-diethyl
• (E)-3,4-epoxyhexane
• trans-3,5-dihydroxy-4'-methoxystilbene
• 1,3-benzenediol-5-[(E)-2-(4-methoxyphenyl)ethenyl]
• 3,4-(methylenedioxy)benzaldoxime
• trans-3,4-Epoxyhexane
• (E)-piperonal oxime
• E-oxime du piperonal
• 5-[(E)-2-(4-Methoxyphenyl)vinyl]benzene-1,3-diol
• 3,4-Epoxyhexane
• (E)-3,5-dihydroxy-4'-methoxystlibene
• 5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol
• Hexane,3,4-epoxy
• resveratrol-4'-methyl ether
• 2,3-diethyl-oxirane
• 5-[(E)-2-(4-Methoxyphenyl)vinyl]-1,3-benzenediol
• (E)-1-(1,3-benzodioxol-5-yl)-N-hydroxymethanimine
• (E)-3,4-methylenedioxybenzaldehyde oxime