3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE

• 常用名: 3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE
• 英文名: 3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE
• CAS号: 341944-06-7
• 分子量: 240.713
• 密度: 1.5±0.1 g/cm3
• 沸点: 488.6±47.0 °C at 760 mmHg
• 分子式: C₉H₉ClN₄S
• 熔点: N/A
• 闪点: 249.3±29.3 °C

用途

抗菌剂117是三唑衍生物,是一种抗菌剂。抗菌剂117的IC50值为15μM,具有对抗普罗瓦泽基酵母菌MetAP1(RpMetAP1)的活性。抗菌剂117还抑制立克次体生长,可用于感染研究[1]。

名称

• 英文名: 3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine

生物活性

• 描述: 抗菌剂117是三唑衍生物,是一种抗菌剂。抗菌剂117的IC50值为15μM,具有对抗普罗瓦泽基酵母菌MetAP1(RpMetAP1)的活性。抗菌剂117还抑制立克次体生长,可用于感染研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 15 μM (RpMetAP1)[1]

• 体外研究: 抗菌剂117可以抑制IC50值为15μM的RpMetAP1[1]。抗菌剂117(0.3μM、3μM、30μM和300μM)刺激内皮细胞(EC)代谢并抑制立克次体生长[1]。
• 参考文献:

  [1]. Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 488.6±47.0 °C at 760 mmHg
• 分子式: C₉H₉ClN₄S
• 分子量: 240.713
• 闪点: 249.3±29.3 °C
• 精确质量: 240.023651
• LogP: 2.41
• InChIKey: ZNOCPAKIRUVGCS-UHFFFAOYSA-N
• SMILES: Nc1nc(SCc2ccccc2Cl)n[nH]1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.699
• 储存条件: 2-8°C

靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Rickettsia prowazekii str. Breinl infected in CD rat p... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3879303

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Rickettsia prowazekii str. Breinl infected with 50:1 m... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3879299

实验名称：Inhibition of Rickettsia prowazekii str. Madrid E N-terminal His-tagged methionine am... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3879300

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

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英文别名

• MFCD00215049
• 3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine
• 5-[(2-Chlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
• MFCD03847132