UBP141

更新时间：2025-08-27 14:24:55

UBP141结构式	常用名	UBP141	英文名	UBP141
	CAS号	344768-30-5	分子量	378.38
	密度	N/A	沸点	N/A
	分子式	C₂₁H₁₈N₂O₅	熔点	N/A
	MSDS	N/A	闪点	N/A

UBP141用途

UBP141是一种GluN2C/2D(NR2C/2D)偏好受体拮抗剂,NMDA受体亚型的Kds分别为2.8、4.2、14.2和19.3μM：GluN2C、2D、2A和2B。UBP141可在WT小鼠中诱导强效运动损伤[1][2]。

英文名	1-(3-Phenanthrylcarbonyl)-2,3-piperazinedicarboxylic acid
英文别名	更多

描述	UBP141是一种GluN2C/2D(NR2C/2D)偏好受体拮抗剂,NMDA受体亚型的Kds分别为2.8、4.2、14.2和19.3μM：GluN2C、2D、2A和2B。UBP141可在WT小鼠中诱导强效运动损伤[1][2]。
相关类别	信号通路 >> 神经信号通路 >> iGluR 研究领域 >> 神经疾病信号通路 >> 跨膜转运 >> iGluR
参考文献	[1]. Morley RM, et, al. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. [2]. Yamamoto H, et, al. Involvement of the N-methyl-D-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity. Mol Brain. 2013 Dec 16;6:56.

描述

UBP141是一种GluN2C/2D(NR2C/2D)偏好受体拮抗剂,NMDA受体亚型的Kds分别为2.8、4.2、14.2和19.3μM：GluN2C、2D、2A和2B。UBP141可在WT小鼠中诱导强效运动损伤[1][2]。

相关类别

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

参考文献

[1]. Morley RM, et, al. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37.

[2]. Yamamoto H, et, al. Involvement of the N-methyl-D-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity. Mol Brain. 2013 Dec 16;6:56.

分子式	C₂₁H₁₈N₂O₅
分子量	378.38
精确质量	378.12200
PSA	106.94000
LogP	2.21150
InChIKey	VVUAQPXBYDYTDF-UHFFFAOYSA-N
SMILES	O=C(O)C1NCCN(C(=O)c2ccc3ccc4ccccc4c3c2)C1C(=O)O

实验名称：Human GluN2B (Ionotropic glutamate receptors)
来源：IUPHAR-DB
靶标：GluN2B (Ionotropic glutamate receptors) [Homo sapiens]
External Id：457_Human

实验名称：Human GluN2A (Ionotropic glutamate receptors)
来源：IUPHAR-DB
靶标：GluN2A (Ionotropic glutamate receptors) [Homo sapiens]
External Id：456_Human

实验名称：Displacement of [3H]-Kainate from wild type rat GluK1 receptor
来源：ChEMBL
靶标：Glutamate receptor ionotropic, kainate 1
External Id：CHEMBL1954500

实验名称：Selectivity ratio of Ki(app) for rat recombinant GluN1/GluN2C receptor to Ki(app) for...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1954489

实验名称：Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL827075

实验名称：Selectivity ratio of Ki(app) for rat recombinant GluN1/GluN2B receptor to Ki(app) for...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1954488

实验名称：Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL827074

实验名称：Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL827073

实验名称：Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL828984

实验名称：Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-m...
来源：ChEMBL
靶标：Glutamate receptor ionotropic, NMDA 1
External Id：CHEMBL828983

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UBP141