xylocytidine

• 常用名: xylocytidine
• 英文名: xylocytidine
• CAS号: 3530-56-1
• 分子量: 243.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₉H₁₃N₃O₅
• 熔点: N/A
• 闪点: N/A

xylocytidine用途

二甲基胞苷是一种胞苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。

xylocytidine名称

• 英文名: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

xylocytidine生物活性

• 描述: 二甲基胞苷是一种胞苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

  [2]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

xylocytidine物理化学性质

• 分子式: C₉H₁₃N₃O₅
• 分子量: 243.22
• 精确质量: 243.08600
• PSA: 131.82000
• InChIKey: UHDGCWIWMRVCDJ-PXBUCIJWSA-N
• SMILES: Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1

xylocytidine靶点实验

查看更多实验

实验名称：Toxicity of compound against mice was determined at a concentration of 2000 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL749907

实验名称：Toxicity of compound against mice was determined at a concentration of 100 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL747599

实验名称：Toxicity of compound against mice was determined at a concentration of 1200 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL747600

实验名称：Number of living cells on the proliferation of mouse myeloma cells SP2 was measured a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL803292

实验名称：Toxicity of compound against mice was determined at a concentration of 750 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL749910

实验名称：Number of living cells on the proliferation of mouse myeloma cells SP2 was measured a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL803291

实验名称：Toxicity of compound against mice was determined at a concentration of 250 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL749909

实验名称：Number of living cells on the proliferation of mouse myeloma cells SP2 was measured a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL803293

实验名称：Number of living cells on the proliferation of mouse myeloma cells SP2 was measured a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL742243

实验名称：Efficacy expressed as number of surviving mice infected with herpetic encephalitis at... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL736927

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xylocytidine英文别名

• Xylocytidine