LDN-0088050

• 常用名: LDN-0088050
• 英文名: LDN-0088050
• CAS号: 353484-30-7
• 分子量: 372.26
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₈BrNO₂
• 熔点: N/A
• 闪点: N/A

LDN-0088050用途

LDN 0088050 是一种选择性的脂肪酸结合蛋白 (AFABP, FABP4) 抑制剂,FABP4、FABP3 的 Ki 值分别为 0.29、1.3 μM. LDN 0088050 结合 FABP4 的Kd 值为 2.05 μM。

LDN-0088050名称

• 英文名: LDN-0088050

LDN-0088050生物活性

• 描述: LDN 0088050 是一种选择性的脂肪酸结合蛋白 (AFABP, FABP4) 抑制剂,FABP4、FABP3 的 Ki 值分别为 0.29、1.3 μM. LDN 0088050 结合 FABP4 的Kd 值为 2.05 μM。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> FABP
• 靶点实验:

  Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1] Kd: 2.05 μM (FABP4)[1]

• 体外研究: LDN 0088050可显著抑制LPS诱导的RAW264.7细胞中TNFα和IL-6的表达[1]。
• 参考文献:

  [1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorg Med Chem. 2016 Sep 15;24(18):4310-4317.

LDN-0088050物理化学性质

• 分子式: C₁₉H₁₈BrNO₂
• 分子量: 372.26
• InChIKey: LBDYSHXIVYPQCI-UHFFFAOYSA-N
• SMILES: O=C(O)C1C2CC=CC2c2cc(Br)cc3c2N1CC1CC=CC31

LDN-0088050靶点实验

查看更多实验

实验名称：Selectivity ratio of Ki for His6-tagged FABP3 (unknown origin) expressed in Escherich... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3828903

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) R106A mutant expresse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3828904

实验名称：Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) R126A mutant expresse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3828905

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Inhibition of FABP4 in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF... 来源：ChEMBL 靶标：Fatty acid-binding protein, adipocyte External Id：CHEMBL3828891

实验名称：Inhibition of FABP4 in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF... 来源：ChEMBL 靶标：Fatty acid-binding protein, adipocyte External Id：CHEMBL3828892

实验名称：Inhibition of FABP4 in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-... 来源：ChEMBL 靶标：Fatty acid-binding protein, adipocyte External Id：CHEMBL3828893

实验名称：Displacement of 1,8-ANS from His6-tagged FABP1 (unknown origin) expressed in Escheric... 来源：ChEMBL 靶标：Fatty acid-binding protein, liver External Id：CHEMBL3828894

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