4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物

• 常用名: 4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物
• 英文名: Methyl 4-hydroxy-2-methyl-(2H)-1,2-benzothiazine-3-carboxylate-1,1-dioxide
• CAS号: 35511-15-0
• 分子量: 269.274
• 密度: 1.5±0.1 g/cm3
• 沸点: 439.9±55.0 °C at 760 mmHg
• 分子式: C₁₁H₁₁NO₅S
• 熔点: 163-165ºC
• 闪点: 219.8±31.5 °C

用途

【用途一】
是合成炎痛喜康等镇痛药物的中间体

名称

• 中文名: 甲基物
• 英文名: methyl 4-hydroxy-2-methyl-1,1-dioxo-1λ6,2-benzothiazine-3-carboxylate
• 中文别名: 2-甲基-4-羟基-2H-1,2-苯并异噻嗪-3-羧酸乙酯-1,1-二氧化物 | 吡罗昔康甲基物 | 甲基4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸盐 1,1-二氧化物 | 2-溴苯甲酸甲酯 | 吡罗昔康杂质J | 2-甲基-4-羟基-2H-1,2-苯并噻唑-3-羧酸甲酯-1,1-二氧化物

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 439.9±55.0 °C at 760 mmHg
• 熔点: 163-165ºC
• 分子式: C₁₁H₁₁NO₅S
• 分子量: 269.274
• 闪点: 219.8±31.5 °C
• 精确质量: 269.035797
• PSA: 92.29000
• LogP: 2.25
• InChIKey: NGHIOTWSWSQQNT-UHFFFAOYSA-N
• SMILES: COC(=O)C1=C(O)c2ccccc2S(=O)(=O)N1C
• 外观性状: 白色粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.632
• 储存条件: -20?C Freezer

MSDS

MSDS英文版

安全信息

• 海关编码: 2934991000

海关

• 海关编码: 2934991000
• 中文概述: 2934991000. 磺内酯及磺内酰胺. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

靶点实验

查看更多实验

实验名称：Selectivity index, ratio of IC50 for MAO-A in rat liver mitochondria to IC50 for MAO-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4141647

实验名称：Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincuba... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL4141645

实验名称：Cell survival assay for modulators of telomere damage signalling 来源：15378 靶标：N/A External Id：TELO_02

实验名称：Inhibition of MAO-B in rat liver mitochondria using p-tyramine as substrate preincuba... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL4141646

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Inhibitors of CDC25B-CDK2/CyclinA interaction 来源：Center for Chemical Genomics, University of Michigan External Id：MScreen:TargetID_600

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

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英文别名

• Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide
• 2H-1,2-Benzothiazine-3-carboxylic acid, 4-hydroxy-2-methyl-, methyl ester, 1,1-dioxide
• methyl 4-hydroxy-2-methyl-1,1-dioxo-2H-1,2-benzothiazine-3-carboxylate
• 2-Methyl-4-Hydroxy-2H-1,2-Benzothiazine-3-Carboxylic Methylester-1,1-Dioxide
• Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide
• 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide
• 4-hydroxy-2-methyl-3-methoxycarbonyl-2H-1,2-benzothiazine-1,1-dioxide
• Methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
• 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic methyl ester-1,1-dioxide
• EINECS 252-601-4
• MFCD00071766