CAY10499

• 常用名: CAY10499
• 英文名: CAY10499
• CAS号: 359714-55-9
• 分子量: 355.345
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₁₇N₃O₅
• 熔点: N/A
• 闪点: N/A

CAY10499用途

MAGL-IN-5是一种非选择性脂肪酶抑制剂,对人类重组单酰甘油脂肪酶(MAGL)、激素敏感脂肪酶(HSL)和脂肪酸酰胺水解酶(FAAH)的IC50值分别为144、90和14 nM[1][2]。

CAY10499名称

• 英文名: cay10499

CAY10499生物活性

• 描述: MAGL-IN-5是一种非选择性脂肪酶抑制剂,对人类重组单酰甘油脂肪酶(MAGL)、激素敏感脂肪酶(HSL)和脂肪酸酰胺水解酶(FAAH)的IC50值分别为144、90和14 nM[1][2]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MAGL
  信号通路 >> 代谢酶/蛋白酶 >> FAAH
  研究领域 >> 代谢疾病
  信号通路 >> 神经信号通路 >> FAAH
• 参考文献:

  [1]. Muccioli GG, et al. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. Chembiochem. 2008 Nov 3;9(16):2704-10.

  [2]. Granchi C, et al. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46.

CAY10499物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₈H₁₇N₃O₅
• 分子量: 355.345
• 精确质量: 355.116821
• PSA: 95.59000
• LogP: 1.97
• InChIKey: QTENHWTVRQKWRI-UHFFFAOYSA-N
• SMILES: COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1
• 折射率: 1.610

CAY10499靶点实验

查看更多实验

实验名称：Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate after ... 来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1 External Id：CHEMBL3423529

实验名称：Inhibition of recombinant human C-terminal His-tagged MAGL expressed in Escherichia c... 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4275246

实验名称：Inhibition of recombinant human MAGL using 4-NPA as substrate after 30 mins by colori... 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4037460

实验名称：Selectivity ratio for human MGL activity to human recombinant FAAH 来源：ChEMBL 靶标：N/A External Id：CHEMBL1036888

实验名称：Irreversible inhibition of human recombinant MAGL using 4-NPA substrate measured afte... 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4681618

实验名称：Irreversible inhibition of human recombinant MAGL pre-incubated for 60 mins before 4-... 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4681620

实验名称：Inhibition of human recombinant MAGL using 4-NPA as substrate after 30 mins 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4424599

实验名称：Cytotoxicity against cancer-derived human organoids in HGSOC patient assessed as redu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4733360

实验名称：Inhibition of human recombinant MAGL using 4-NPA substrate incubated for 30 mins 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4681616

实验名称：Antiproliferative activity against human HCT116 cells as reduction in cell growth mea... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4733355

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CAY10499英文别名

• Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
• Benzyl [4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate