二氢血根碱

• 常用名: 二氢血根碱
• 英文名: dihydrosanguinarine
• CAS号: 3606-45-9
• 分子量: 333.337
• 密度: 1.4±0.1 g/cm3
• 沸点: 566.9±29.0 °C at 760 mmHg
• 分子式: C₂₀H₁₅NO₄
• 熔点: N/A
• 闪点: 176.8±21.5 °C

二氢血根碱用途

二氢血根碱(Dihydrosanguinarine)是榕树叶片提取出的天然化合物,有抗真菌和抗增殖等活性报道。

二氢血根碱名称

• 中文名: 13,14-二氢血根碱
• 英文名: dihydrosanguinarine

二氢血根碱生物活性

• 描述: 二氢血根碱(Dihydrosanguinarine)是榕树叶片提取出的天然化合物,有抗真菌和抗增殖等活性报道。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 感染
• 参考文献:

  [1]. Vrba J, et al. Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells. Toxicol In Vitro. 2009 Jun;23(4):580-8.

  [2]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.

  [3]. Vrublova E, et al. The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study. Food Chem Toxicol. 2008 Jul;46(7):2546-53.

  [4]. Fuchino H, et al. In vitro leishmanicidal activity of benzophenanthridine alkaloids from Bocconia pearcei and related compounds. Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1047-50.

二氢血根碱物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 566.9±29.0 °C at 760 mmHg
• 分子式: C₂₀H₁₅NO₄
• 分子量: 333.337
• 闪点: 176.8±21.5 °C
• 精确质量: 333.100098
• PSA: 40.16000
• LogP: 4.68
• InChIKey: CIUHLXZTZWTVFL-UHFFFAOYSA-N
• SMILES: CN1Cc2c(ccc3c2OCO3)-c2ccc3cc4c(cc3c21)OCO4
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.720
• 储存条件: 2-8℃

二氢血根碱靶点实验

查看更多实验

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Antimicrobial activity against Penicillium oxalicum CBS 219.30 at 25 ug 来源：ChEMBL 靶标：Penicillium oxalicum External Id：CHEMBL1019284

实验名称：Antiproliferative activity against human A549 cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4699783

实验名称：Antimicrobial activity against Micrococcus luteus ATCC 9341 at 25 ug 来源：ChEMBL 靶标：Micrococcus luteus External Id：CHEMBL1019286

实验名称：Antimicrobial activity against Bacillus subtilis ATCC 6633 at 25 ug 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL1019285

实验名称：Antiproliferative activity against human H1975 cells assessed as inhibition of cell g... 来源：ChEMBL 靶标：NCI-H1975 External Id：CHEMBL4699784

实验名称：Cytotoxicity against human HGF cells assessed as cell growth inhibition at 50 uM afte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4191684

实验名称：Antimicrobial activity against Escherichia coli ATCC 25922 at 25 ug 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1019287

实验名称：Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine... 来源：ChEMBL 靶标：Aromatic-L-amino-acid decarboxylase External Id：CHEMBL3295577

实验名称：Inhibition of human erythrocyte AChE using S-acetylthiocholine iodide as substrate pr... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4144749

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二氢血根碱英文别名

• dihydrosanguinarine
• 13-Methyl-13,14-dihydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridine
• dihydroavicine
• Dihydro Sanguinarine
• 3lle
• Hydrosanguinarine