G3335

• 常用名: G3335
• 英文名: G3335
• CAS号: 36099-95-3
• 分子量: 333.33900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₉N₃O₅
• 熔点: N/A
• 闪点: N/A

G3335用途

H类-​Trp公司-​谷氨酸-​OH是一种选择性、可逆和细胞通透性的PPARγ,Kd约为8µM.H-​Trp公司-​谷氨酸-​OH可能是糖尿病研究中的一种潜在先导化合物[1]。

G3335名称

• 中文名: H-TRP-GLU-OH
• 英文名: 2-[[2-amino-3-(1H-indol-3-yl)propanoyl]amino]pentanedioic acid

G3335生物活性

• 描述: H类-​Trp公司-​谷氨酸-​OH是一种选择性、可逆和细胞通透性的PPARγ,Kd约为8µM.H-​Trp公司-​谷氨酸-​OH可能是糖尿病研究中的一种潜在先导化合物[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
  研究领域 >> 代谢疾病
• 靶点实验:

  PPARγ:8 μM (Kd)

• 参考文献:

  [1]. Ye F, et al. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation. Chembiochem. 2006 Jan;7(1):74-82.

G3335物理化学性质

• 分子式: C₁₆H₁₉N₃O₅
• 分子量: 333.33900
• 精确质量: 333.13200
• PSA: 145.51000
• LogP: 1.56310
• InChIKey: PWIQCLSQVQBOQV-AAEUAGOBSA-N
• SMILES: NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCC(=O)O)C(=O)O
• 外观性状: 白色至类白色粉末
• 储存条件: -20℃

G3335安全信息

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

G3335海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

G3335靶点实验

查看更多实验

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as increase of... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292019

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as increase of... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292018

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as increase of... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292021

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as increase of... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292020

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as increase of... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292023

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as increase of... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292022

实验名称：Percent inhibition of Dipeptidyl peptidase IV (DPP IV) at a concentration of 10 uM 来源：ChEMBL 靶标：Dipeptidyl peptidase 4 External Id：CHEMBL857575

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as induction o... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3292024

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as reduction o... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3291743

实验名称：Agonist activity at PPARalpha in lipid loaded rat HII4E cells assessed as reduction o... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3291742

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G3335英文别名

• PPARgamma Antagonist III,G3335
• IN1159
• TRP-GLU
• tryptophylglutamic acid
• L-tryptophyl-L-glutamic acid
• H-Trp-Glu-OH
• PPARg Antagonist III,G3335